Study type: Medical/biological study (experimental study)

Transient and cumulative memory impairments induced by GSM 1.8 GHz cell phone signal in a mouse model. med./bio.

Published in: Electromagn Biol Med 2013; 32 (1): 95-120

Aim of study (acc. to author)

To examine memory impairments in mice exposed to a radiofrequency electromagnetic field.

Background/further details

In two experiments, three groups of mice were examined, respectively (n=8 per group): 1.) control group (in a seperate room), 2.) sham exposure + auditory stimulation (70 db) and 3.) exposure + auditory stimulation (70 db). Auditory stimulation was given to simulate human voice during cell phone operation.
The first experiment started after an acclimatization period from postnatal days 45 to 59. The exposure started at day 59 and lasted until day 125. During this exposure period, mice were tested thrice for potential memory impairments (testing 1a: postnatal days 59-63, testing 1b: postnatal days 88-92, testing 1c: postnatal days 121-125).
To test whether the potential memory impaiments were transient or permanent, the second experiment was performed. It started after an acclimatization period from postnatal days 45 to 69. Mice were exposed every day from postnatal days 76 to 130 and every second day from postnatal days 183 to 212. Before the first exposure period, mice were tested for potential memory impairments (testing 2a: postnatal days 69-73). Additionally, mice were tested for potential memory impairments during the first exposure period (testing 2b: postnatal days 100-104), twice between the exposure periods (testing 2c: postnatal days 140-144, testing 2d: postnatal days 168-172) and a fifth time after the second exposure period (testing 2e: postnatal days 213-217).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Exposure duration: 90 min/day every day or every second day for up to 83 days (detailed description in "aim of study")

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Charakteristic
Exposure duration 90 min/day every day or every second day for up to 83 days (detailed description in "aim of study")
Exposure setup
Exposure source
Chamber 4 mice per cage
Setup mobile phone was placed under each cage; cages were placed within specially constructed rectangular one-side opened Faraday cages
Sham exposure A sham exposure was conducted.
Additional info cages containing the sham exposed mice located at the other side of the room within rectangular complete Faraday cages; during exposure and sham exposure auditory stimulation (70 db) was generated by a playing radio station (to simulate human voice during mobile phone operation)
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.11 W/kg effective value calculated - -
electric field strength 12 V/m average over time measured - within the cages

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

In the first experiment, the exposed animals showed a significant reduced memory performance in the second (1b) and the third testing (1c) in the spatial and the non-spatial test when compared to the control group. No significant differences were found between the control group and the sham exposed group or in the testing 1a. In the second experiment, the exposed mice showed significant memory impairments when tested during the first exposure period and when tested the first time after the first exposure period in the spatial and in the non-spatial test (testing 2b and 2c). No significant differences were found between the control group and the sham exposed group or in the testings 2a, 2d and 2e.
The authors conclude that exposure to radiofrequency electromagnetic fields could induce spatial and non-spatial transient memory impairments in mice.

Study character:

Study funded by

Related articles