Study type: Medical/biological study (experimental study)

Short-term memory in mice is affected by mobile phone radiation. med./bio.

Published in: Pathophysiology 2011; 18 (3): 193-199

Aim of study (acc. to author)

To study whether real mobile phone exposure affects the object recognition memory in mice. The objects consisted of cubes, pyramides and cylinders of different colours.

Background/further details

The object recognition task consists of a habituation session (day 1), a training session (acquisition phase with two identical objects; day 2) and a test session (day 3). Day 3 consists of two trials (one trial with familiar objects and one trial with a familiar and a novel object) and an inter-trial interval (for memory consolidation).
Mice were divided into three groups (8 animals per group: exposed, sham exposed and control) and the object recognition task was performed according to the following three protocols: 1) "acute exposure": mice (45 days old) were exposed to the mobile phone during the habituation, the training and the test sessions, but not during the 10 min inter-trial interval (memory consolidation phase); 2) "chronic exposure-I": the same mice were exposed for 17 days for 90 min/per day starting at postnatal day 55 to the same mobile phone irradiation. The object recognition task was performed at postnatal day 72 with irradiation present only during the inter-trial interval phase; 3) "chronic exposure-II": mice were continuously exposed daily under the same conditions up to postnatal day 86 (total exposure duration: 31 days). One day later the object recognition task test was performed without irradiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Exposure duration: 90 min/day for 3 days (acute exposure), 17 days (chronic exposure-I) or 31 days (chronic exposure-II)

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration 90 min/day for 3 days (acute exposure), 17 days (chronic exposure-I) or 31 days (chronic exposure-II)
Exposure setup
Exposure source
Chamber sound proof, air-conditioned room
Setup 8 animals kept in a 267 mm x 207 mm x 140 mm Plexiglas cage placed in a half-open Faraday cage; mobile phone placed under the cage or the ORT (object recognition test) apparatus; radio playing during exposure to simulate human voice during mobile phone use
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 17 V/m average over time measured - averaged over 6 min
SAR 0.22 W/kg average over mass calculated brain -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The data revealed a major effect of the "chronic exposure-I" suggesting a possible severe effect of the electromagnetic field on the memory consolidation phase of the recognition memory process. This may imply that the primary electromagnetic field target may be the entorhinal-hippocampal regions which participate in the object recognition.

Study character:

Study funded by

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