本研究は、携帯電話信号がマウスの空間および非空間記憶の障害に及ぼす一過性および蓄積性の影響を調べた動物実験である。自由に動き回る2月齢の雄のC57Bl/6Jマウスを2種類の実験プロトコル（66日間および148日間）で、比吸収率（SAR）0.11W/kgのGSM1.8GHz信号に90分／日ばく露した。SAR=0.11W/kgについては、ケージ内での平均電界強度12V/m（6分間測定の平均値）に基づき、頭部組織の導電率σ=0.8S/m、比重ρ=1040kg/m３として算出したと述べている。各プロトコルにつき、3群（ばく露群、偽ばく露群、対照群、各8匹）に、2つの行動学的パラダイム（物体認識タスクおよび物体位置課題を異なる時点で順番に実施した）を組合せた。その結果、実験の進行とともに両タイプの記憶障害の蓄積が統計的に有意にみられ、特に空間記憶で顕著であった；この障害は、8週間にわたる毎日のばく露を停止してから2週間後まで残ったが、両タスクで検出されたマウスの記憶は約1か月後には完全に回復した；1日おきの1か月間の間欠ばく露には、両タイプの記憶への影響はなかった、と報告している。
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To examine memory impairments in mice exposed to a radiofrequency electromagnetic field.
In two experiments, three groups of mice were examined, respectively (n=8 per group): 1.) control group (in a seperate room), 2.) sham exposure + auditory stimulation (70 db) and 3.) exposure + auditory stimulation (70 db). Auditory stimulation was given to simulate human voice during cell phone operation.
The first experiment started after an acclimatization period from postnatal days 45 to 59. The exposure started at day 59 and lasted until day 125. During this exposure period, mice were tested thrice for potential memory impairments (testing 1a: postnatal days 59-63, testing 1b: postnatal days 88-92, testing 1c: postnatal days 121-125).
To test whether the potential memory impaiments were transient or permanent, the second experiment was performed. It started after an acclimatization period from postnatal days 45 to 69. Mice were exposed every day from postnatal days 76 to 130 and every second day from postnatal days 183 to 212. Before the first exposure period, mice were tested for potential memory impairments (testing 2a: postnatal days 69-73). Additionally, mice were tested for potential memory impairments during the first exposure period (testing 2b: postnatal days 100-104), twice between the exposure periods (testing 2c: postnatal days 140-144, testing 2d: postnatal days 168-172) and a fifth time after the second exposure period (testing 2e: postnatal days 213-217).
| 周波数 | 1,800 MHz |
|---|---|
| タイプ |
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| 特性 |
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| ばく露時間 | 90 min/day every day or every second day for up to 83 days (detailed description in "aim of study") |
| ばく露の発生源／構造 |
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|---|---|
| チャンバの詳細 | 4 mice per cage |
| ばく露装置の詳細 | mobile phone was placed under each cage; cages were placed within specially constructed rectangular one-side opened Faraday cages |
| Sham exposure | A sham exposure was conducted. |
| Additional information | cages containing the sham exposed mice located at the other side of the room within rectangular complete Faraday cages; during exposure and sham exposure auditory stimulation (70 db) was generated by a playing radio station (to simulate human voice during mobile phone operation) |
In the first experiment, the exposed animals showed a significant reduced memory performance in the second (1b) and the third testing (1c) in the spatial and the non-spatial test when compared to the control group. No significant differences were found between the control group and the sham exposed group or in the testing 1a. In the second experiment, the exposed mice showed significant memory impairments when tested during the first exposure period and when tested the first time after the first exposure period in the spatial and in the non-spatial test (testing 2b and 2c). No significant differences were found between the control group and the sham exposed group or in the testings 2a, 2d and 2e.
The authors conclude that exposure to radiofrequency electromagnetic fields could induce spatial and non-spatial transient memory impairments in mice.
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