Study type: Medical/biological study (observational study)

Connection between Cell Phone use, p53 Gene Expression in Different Zones of Glioblastoma Multiforme and Survival Prognoses. med./bio.

Published in: Rare Tumors 2014; 6 (3): 5350

Aim of study (acc. to author)

The relationship between usage time of cell phones, p53 expression in tumor cells and survival time of glioblastoma patients should be investigated.

Background/further details

The removed tumors of 63 glioblastoma patients (38 male and 25 female) with an average age of 55 years were investigated. Additionally, every patient filled out a questionnaire which provided, among other things, information on the usage of cell phones.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 800–1,900 MHz
Exposure duration: repeated daily exposure of less than 3 hours
  • SAR: 1.42 W/kg mean
  • SAR: 1.53 W/kg maximum
  • SAR: 0.66 W/kg minimum
Exposure 2: 800–1,900 MHz
Exposure duration: repeated daily exposure of more than 3 hours
  • SAR: 1.42 W/kg mean
  • SAR: 1.53 W/kg maximum
  • SAR: 0.66 W/kg minimum

Exposure 1

Main characteristics
Frequency 800–1,900 MHz
Type
Exposure duration repeated daily exposure of less than 3 hours
Exposure setup
Exposure source
Setup duration of daily usage of cell phone was acquired via questionnaire
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.42 W/kg mean calculated - -
SAR 1.53 W/kg maximum measured - -
SAR 0.66 W/kg minimum measured - -

Exposure 2

Main characteristics
Frequency 800–1,900 MHz
Type
Exposure duration repeated daily exposure of more than 3 hours
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.42 W/kg mean - - -
SAR 1.53 W/kg maximum - - -
SAR 0.66 W/kg minimum - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

93.6% of the investigated tumors expressed a p53 mutation with a loss of the normal protein function, which was a significant correlation. Moreover, 65% of the patients who used their cell phone more than 3 hours per day showed a significantly higher mutant p53 expression in the peripheral zone of the tumor compared to the expression in the central zone, which was in turn significantly correlated with a shorter overall survival time.
The authors conclude that these results show a relationship between cell phone use, the occurrence of p53 in the peripheral zone of glioblastomas and the overall survival time and that further studies should address this topic more accurately.

Study character:

Study funded by

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