Study type: Medical/biological study (experimental study)

Long term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain. med./bio.

Published in: Int J Radiat Biol 2015; 91 (4): 306-311

Aim of study (acc. to author)

The effects of a chronic exposure of rats to a 900 MHz electromagnetic field on the expression of some microRNAs in the brain should be investigated.

Background/further details

MicroRNAs are small, non-coding RNA molecules, which play a critical role in gene regulation and could be related to the development of cancer and neurodegenerative diseases.
14 rats were divided into two groups (n=7 each): exposure and sham exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 3 h/day on 7 days/week for 12 months

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 3 h/day on 7 days/week for 12 months
Exposure setup
Exposure source
Distance between exposed object and exposure source 1 cm
Chamber rats were confined in a Plexiglas carousel with the antenna in the center; carousel was surrounded by electromagnetic absorber material backed by metal for isolation from environmental electromagnetic fields
Setup distance from the antenna to the head of the rats was 1 cm; signal was emitted omnidirectional on the plane perpendicular to the antenna axis; temperature was maintained at 22°C and the relative humidity was maintained at 45%
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.198 W/kg peak value measured and calculated - in brain
SAR 0.143 W/kg mean measured and calculated 1 g in brain
SAR 0.114 W/kg mean measured and calculated 10 g in brain
SAR 0.0369 W/kg effective value measured and calculated whole body -
SAR 2.023 W/kg maximum measured and calculated whole body ± 0.121 W/kg

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The expression rate of rno-miR-107 was significantly reduced in the exposure group compared to sham exposure. The expression rates of the other investigated microRNAs were not significantly different in the two groups.
The authors conclude that a chronic exposure of rats to a 900 MHz electromagnetic field could influence the expression of some microRNAs in the brain.

Study character:

Study funded by

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