Study type: Medical/biological study (experimental study)

Studying gene expression profile of rat neuron exposed to 1800 MHz radiofrequency electromagnetic fields with cDNA microassay. med./bio.

Published in: Toxicology 2007; 235 (3): 167-175

Aim of study (acc. to author)

To study whether 1800 MHz radiofrequency electromagnetic fields can influence the gene expression of neurons.

Background/further details

Cerebral cortical and hippocampal tissues were harvested from three Sprague-Dawley rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: pulsed
Exposure duration: intermittent, 5 min on/10 min off, for 24 h

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Charakteristic
  • guided field
Exposure duration intermittent, 5 min on/10 min off, for 24 h
Modulation
Modulation type pulsed
Duty cycle 12.5 %
Repetition frequency 217 Hz
Pulse type rectangular
Additional info

GSM signal

Exposure setup
Exposure source
Chamber Two waveguides were placed inside a conventional incubator (37 °C, 5% CO2 and 95% air) and were blindly selected for RF or sham exposure.
Setup Six 35-mm dishes per waveguide were placed in the H-field maxima and exposed in E polarisation.
Sham exposure A sham exposure was conducted.
Additional info The RF exposure system has been described by other groups [Schonborn et al., 2001].
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 W/kg mean - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:

Main outcome of study (acc. to author)

Among 1200 candidate genes, 24 up-regulated genes and 10 down-regulated genes were identified after exposure, which are associated with multiple cellular functions. The data were further confirmed by RT-PCR. The findings indicated that the gene expression of rat neuron could be altered by exposure to radiofrequency electromagnetic fields under the present experimental conditions.

Study character:

Study funded by

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