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The effects of a chronic exposure of rats to a 900 MHz electromagnetic field on the expression of some microRNAs in the brain should be investigated.
MicroRNAs are small, non-coding RNA molecules, which play a critical role in gene regulation and could be related to the development of cancer and neurodegenerative diseases.
14 rats were divided into two groups (n=7 each): exposure and sham exposure.
|ばく露時間||continuous for 3 h/day on 7 days/week for 12 months|
|Distance between exposed object and exposure source||1 cm|
|チャンバの詳細||rats were confined in a Plexiglas carousel with the antenna in the center; carousel was surrounded by electromagnetic absorber material backed by metal for isolation from environmental electromagnetic fields|
|ばく露装置の詳細||distance from the antenna to the head of the rats was 1 cm; signal was emitted omnidirectional on the plane perpendicular to the antenna axis; temperature was maintained at 22°C and the relative humidity was maintained at 45%|
|Sham exposure||A sham exposure was conducted.|
The expression rate of rno-miR-107 was significantly reduced in the exposure group compared to sham exposure. The expression rates of the other investigated microRNAs were not significantly different in the two groups.
The authors conclude that a chronic exposure of rats to a 900 MHz electromagnetic field could influence the expression of some microRNAs in the brain.