Medical/biological study (experimental study)

Examination of the Effect of a 50-Hz Electromagnetic Field at 500 μT on Parameters Related With the Cardiovascular System in Rats med./bio.

By: Zhang Y, Li L, Liu X, Ding L, Wu X, Wang J, He M, Hou H, Ruan G, Lai J, Chen C

Published in: Front Public Health 2020; 8: 87

Aim of study (acc. to author)

The effects of exposure of rats to a 50 Hz magnetic field on the cardiovascular system should be investigated.

Background/further details

Male rats were divided into an exposure group (n=24) and a sham exposure group (n=24). Blood pressure and heart rate were measured every 4 weeks, alle other parameters were measured once after exposure.

Endpoint

effects on the cardiovascular system: cardiac function as well as morphological and molecular changes

Exposure

- 50/60 Hz
- magnetic field

Exposure	Parameters
Exposure 1: 50 Hz Exposure duration: 24 weeks (20 hours/day)	magnetic flux density: 500 µT

Exposure 1

Main characteristics

Frequency	50 Hz
Exposure duration	24 weeks (20 hours/day)

Exposure setup

Exposure source	not specified
Sham exposure	A sham exposure was conducted.

Parameters

Measurand	Value	Type	Method	Mass	Remarks
magnetic flux density	500 µT	-	-	-	-

Reference articles

Zhou L et al. (2016): The effects of a 50-Hz magnetic field on the cardiovascular system in rats

Exposed system:

animal
rat/Sprague Dawley

Methods Endpoint/measurement parameters/methodology

effects on the cardiovascular system: cardiac function: systolic blood pressure, diastolic blood pressure, mean pressure and heart rate (every 4 weeks), cardiac rhythm (electrocardiography), echocardiography, hemodynamics of left ventricle (ejection fraction, fractional shortening, left ventricular internal diameter, thickness of the interventricular septum and left ventricular posterior wall; cardiac catheterization); morphology and arrangement of cardio-myocytes (hematoxylin-eosin stain, microscopy); gene expression and protein expression of cardiac remodeling-related genes (ANP, BNP and Myh6; quantitative RT-PCR and Western Blot), ratio of heart weight to body weight

Investigated system:

tissue slices
isolated organ
DNA/RNA
heart
investigation on living organism

Investigated organ system:

cardiovascular system

Time of investigation:

during exposure
after exposure

Main outcome of study (acc. to author)

There were no significant differences between the exposure group and the sham exposure group in any parameter.
The authors conclude that no effects of exposure of rats to a 50 Hz magnetic field on the cardiovascular system were found.

Study character:

medical/biological study
experimental study
full/main study

Study funded by

National Natural Science Foundation (NSFC), China
State Grid Corporation, China (SGCC)

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