The aim of the study was to investigate the therapeutic action of an extract of rosemary (Rosmarinus officinalis) leaves against harmful electric field-induced effects in rats.
48 rats were divided into six groups (each group n=8): 1) control group, 2) rosemary group (5 mg/kg body weight per day for 25 days), 3) rats exposed 2 h per day to the electric field for 25 days, 4) rats exposed 4 h per day for 25 days, 5) rats co-exposed 2 h per day for 25 days to the electric field and to rosemary extracts for 5 days before exposure and during exposure, 6) rats co-exposed 4 h per day for 25 days to the electric field and to rosemary extracts for 5 days before exposure and during exposure.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
2 h or 4 h per day for 25 day (5 days/week)
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | 2 h or 4 h per day for 25 day (5 days/week) |
| Exposure source | |
|---|---|
| Setup | exposure set-up consisted of two plates: the upper plate was made from copper and the lower one from aluminum; the cage with the 8 rats was put between the plates; distance between the two plates was 1.8 m; the cage was made from plastic (46 cm long, 16 cm wide, and 20 cm high) |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 5.4 kV/m | - | - | - | - |
The data showed that the electric field exposure induced a substantial decrease in red blood cells, haemoglobin concentration, packed cell volume, and catalase activity, whereas white blood cells, aspartate aminotransferase enzyme activity, alanine aminotransferase enzyme activity, total bilirubin, urea, creatinine, uric acid, protein, albumin, and malondialdehyde levels were increased significantly under electric field exposure. Treatment with rosemary showed an attenuation of these changes. The histopathological data showed that the electric field exposure induced many damages to liver cell tissues and rosemary administration reduced these changes.
The authors concluded that an extract of rosemary leaves offered substantial protection against electric field induced liver damage.
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