The effects of exposure to a 50 Hz electric field on the kidneys of mice should be investigated.
Mice were randomly divided into the following groups: exposure to the electric field for 1) 7 days (n=10), 2) 14 days (n=10), 3) 21 days (n=10), 4) 25 days (n=8), 5) 35 days (n=10), 6) 49 days (n=10) and 7) 52 days (n=8). For each exposure group, a separate control group with the same number of mice was used.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
continuously for 7 to 52 days
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Exposure duration | continuously for 7 to 52 days |
| Exposure source | |
|---|---|
| Setup | the electrode unit was composed of upper and lower plates with a diameter of 3 m; mice were placed on the lower inside plastic buckets |
| Additional info | mice of the control groups were placed on the ground below the lower plate in plastic buckets |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| electric field strength | 35 kV/m | mean | measured | - | ± 0.9 kV/m (SD) at 8 cm above the bottom of buckets |
The serum levels of urea nitrogen and creatinine were significantly increased after 21 and 35 days (groups 3 and 5) and 14, 21 and 35 days (groups 2, 3 and 5) of exposure, respectively, compared to the control groups. However, the concentrations of creatinine and urea nitrogen both returned to normal levels after 49 days of exposure (group 6). Moreover, an enlarged Bowman's space, vacuolation of renal tubular epithelial cells and the foot process effacement of podocyte were found after 25 days of expsoure (group 4), but no abnormalities were observed after 52 days of exposure (group 7) compared to the respective control groups.
The authors conclude that a short-term exposure of mice to a 50 Hz electric field could cause kidney injury, which could recover after a longer-term exposure.
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