Study type: Medical/biological study (experimental study)

Effects of power frequency electric field exposure on kidney med./bio.

Published in: Ecotoxicol Environ Saf 2020; 194: 110354

Aim of study (acc. to author)

The effects of exposure to a 50 Hz electric field on the kidneys of mice should be investigated.

Background/further details

Mice were randomly divided into the following groups: exposure to the electric field for 1) 7 days (n=10), 2) 14 days (n=10), 3) 21 days (n=10), 4) 25 days (n=8), 5) 35 days (n=10), 6) 49 days (n=10) and 7) 52 days (n=8). For each exposure group, a separate control group with the same number of mice was used.



Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuously for 7 to 52 days

Exposure 1

Main characteristics
Frequency 50 Hz
Exposure duration continuously for 7 to 52 days
Exposure setup
Exposure source
Setup the electrode unit was composed of upper and lower plates with a diameter of 3 m; mice were placed on the lower inside plastic buckets
Additional info mice of the control groups were placed on the ground below the lower plate in plastic buckets
Measurand Value Type Method Mass Remarks
electric field strength 35 kV/m mean measured - ± 0.9 kV/m (SD) at 8 cm above the bottom of buckets

Reference articles

  • Di G et al. (2019): A comparative study on influences of static electric field and power frequency electric field on cognition in mice
  • Di G et al. (2018): A comparative study on effects of static electric field and power frequency electric field on hematology in mice

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The serum levels of urea nitrogen and creatinine were significantly increased after 21 and 35 days (groups 3 and 5) and 14, 21 and 35 days (groups 2, 3 and 5) of exposure, respectively, compared to the control groups. However, the concentrations of creatinine and urea nitrogen both returned to normal levels after 49 days of exposure (group 6). Moreover, an enlarged Bowman's space, vacuolation of renal tubular epithelial cells and the foot process effacement of podocyte were found after 25 days of expsoure (group 4), but no abnormalities were observed after 52 days of exposure (group 7) compared to the respective control groups.
The authors conclude that a short-term exposure of mice to a 50 Hz electric field could cause kidney injury, which could recover after a longer-term exposure.

Study character:

Study funded by

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