To investigate the influence of 50 Hz electric fields on the oxidative/antioxidative balance of internal organs of rats.
Two groups of male rats were investigated (n=10 per group): A sham exposure group and an exposure group.
Exposure | Parameters |
---|---|
Exposure 1:
50 Hz
Exposure duration:
22 hours/day for 28 consecutive days
|
|
Frequency | 50 Hz |
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Type | |
Exposure duration | 22 hours/day for 28 consecutive days |
Exposure source | |
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Chamber | rats were exposed in a plastic cage (10 animals per cage) which did not disturb the electric field |
Setup | cages were put between two electrodes (distance 50 cm) |
Sham exposure | A sham exposure was conducted. |
Additional info | sham exposed animals were also put between electrodes in a plastic cage, but no voltage was generated |
Measurand | Value | Type | Method | Mass | Remarks |
---|---|---|---|---|---|
electric field strength | 10 kV/m | - | - | - | - |
In kidney tissue homogenates of exposed rats, the total oxidant capacitiy and the enzyme activities of superoxide dismutase and glutathione peroxidase were significantly increased while the enzyme activities of glutathione reductase and glutathione S-transferase were significantly decreased, as compared to sham exposed rats.
In heart tissue homogenates of exposed rats, a significant decrease in the total oxidant capacity and in the enzyme activity of the glutathione S-transferase were found when compared to the sham exposed rats, while the enzyme activity of the glutathione peroxidase was significantly increased.
In lung homogenates of exposed rats, the lipid peroxidation and the enzyme activity of the catalase were significantly increased compared to sham exposed animals.
The authors conclude that 4-weeks exposure to 50 Hz electric fields promote oxidant processes in organs of rats accompanied with compensatory antioxidant enzyme activities.
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