Study type: Medical/biological study (experimental study)

Effect of global system for mobile communication (gsm)-like radiofrequency fields on vascular permeability in mouse brain. med./bio.

Published in: Pathology 2001; 33 (3): 338-340

Aim of study (acc. to author)

To study the effect of GSM radiofrequency fields on vascular permeability in the mouse brain.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 898.4 MHz
Modulation type: pulsed
Exposure duration: continuous for 60 min
  • SAR: 4 W/kg unspecified (whole body)

Exposure 1

Main characteristics
Frequency 898.4 MHz
Type
Charakteristic
Exposure duration continuous for 60 min
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Exposure setup
Exposure source
Setup The exposure system consisted of a cylindrical parallel plate with mice restrained in clear Perspex tubes, preventing them from changing their orientation, and arranged radially around the dipole antenna. A forced air supply was maintained through the cylinders to ensure no heat build-up, and it was confirmed that the core body temperature did not rise using a Luxtron.
Additional info Both exposed and sham-exposed groups were placed in the system, while control mice were neither restrained nor exposed and were able to move freely in their cages. In a positive control group, mice were given Clostridium perfringens type D epsilon toxin.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4 W/kg unspecified estimated whole body -

Reference articles

  • Balzano Q et al. (2000): An efficient RF exposure system with precise whole-body average SAR determination for in vivo animal studies at 900 MHz.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The study showed that exposure of mice to a GSM-like radiofrequency field of 4 W/kg for 1 hour did not significantly disrupt blood-brain barrier integrity when evaluated by albumin immunohistochemistry at the light microscope level. In both exposed and non-exposed animals, albumin leakage occured predominantly from non blood-brain barrier, leptomeningeal venules.

Study character:

Study funded by

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