Study type: Medical/biological study (experimental study)

Effects of sinusoidal electromagnetic field on structure and function of different kinds of cell lines. med./bio.

Published in: Yonsei Med J 2006; 47 (6): 852-861

Aim of study (acc. to author)

To investigate the effects of a 2 mT, 60 Hz sinusoidal electromagnetic field on the structure and function of four kinds of human cell lines in vitro.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 1, 3, 6 h/day for 7 or 14 days

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration 1, 3, 6 h/day for 7 or 14 days
Exposure setup
Exposure source
Setup solenoid coil (inner diameter 20 cm, height 24 cm) placed in an incubator; cells placed coaxially with the center-line in the central area of the coils; EMF perpendicular to the cell plates.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT - measured - deviation < 3%

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data obtained indicated a cell type-specific reaction to electromagnetic field exposure. In addition, the cellular responses were dependent on exposure duration.
Electromagnetic field treatment promoted growth of the human fetal osteoblasts and the human cortical neuronal cells compared with control group at 7 and 14 days of incubation. When the exposure time was 3 hours/day increased proliferation of B lymphoblasts but decreased proliferation of smooth muscle cells was observed.
On the other hand, the effects of electromagnetic field on cell cycle distribution, cell differentiation, and cellular actin filament distribution remained unclear. Furthermore, no effects of electromagnetic field exposure on gap junctional intercellular communication was found.

Study character:

Study funded by

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