Amphetamine can increase the reduced glutathione content and a pro-oxidative effect of amphetamine has been reported.
Two of four groups of rats (n=6 per group) were exposed (the remaining two groups were sham exposed) and immediately after the exposure (or sham exposure), two groups (exposed and sham-exposed) were treated with D-amphetamine.
Exposure duration: continuous for 7 day
Magnetic field exposure induced a significant decrease in glutathione only in the cortex. Amphetamine alone did not change the glutathione content. When it was given after extremely low frequency electromagnetic field exposure, glutathione depletion in the cortex induced by magnetic field exposure was completely prevented. Furthermore, the glutathione content was increased in the brainstem and cerebellum of animals treated with "magnetic field exposure + amphetamine" compared to the others groups (sham exposure, exposure alone, amphetamine alone).
The data indicate that biogenic monoamines are involved in the glutathione content changes observed. The changes are not uniform in the brain regions examined.