Study type: Medical/biological study (experimental study)

The effects of exposure to extremely low-frequency magnetic field and amphetamine on the reduced glutathione in the brain. med./bio.

Published in: Ann N Y Acad Sci 2005; 1048: 377-380

Aim of study (acc. to editor)

To study the effect of continuous exposure to an extremely low frequency magnetic field alone and combined with D-amphetamine (1.5 mg/kg) on reduced glutathione content in six brain regions of rats.

Background/further details

Amphetamine can increase the reduced glutathione content and a pro-oxidative effect of amphetamine has been reported.
Two of four groups of rats (n=6 per group) were exposed (the remaining two groups were sham exposed) and immediately after the exposure (or sham exposure), two groups (exposed and sham-exposed) were treated with D-amphetamine.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 7 day

General information

Rats were divided into four group (n=6/group), 2 groups were exposed to MF, the remaining two were sham exposed.

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 7 day
Exposure setup
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.5 mT unspecified unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Magnetic field exposure induced a significant decrease in glutathione only in the cortex. Amphetamine alone did not change the glutathione content. When it was given after extremely low frequency electromagnetic field exposure, glutathione depletion in the cortex induced by magnetic field exposure was completely prevented. Furthermore, the glutathione content was increased in the brainstem and cerebellum of animals treated with "magnetic field exposure + amphetamine" compared to the others groups (sham exposure, exposure alone, amphetamine alone).
The data indicate that biogenic monoamines are involved in the glutathione content changes observed. The changes are not uniform in the brain regions examined.

Study character:

Study funded by

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