Study type: Medical/biological study (experimental study)

Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study. med./bio.

Published in: J Photochem Photobiol B 2004; 73 (1-2): 43-48

Aim of study (acc. to author)

The effects of exposure of mice to a 60 Hz magnetic field on oxidative stress and the antioxidative defense in the brain should be investigated.

Background/further details

Mice were divided into two groups (n=14 each): an exposure group and a sham exposure group.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous for 3 hours

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration continuous for 3 hours
Exposure setup
Exposure source
Chamber cage made of non-magnetic material
Setup Helmholtz coils (1 m2, 100 turns of 1 mm copper wire) were embedded in an open wooden rectangular frame; each winding was split allowing the current to flow in the same sense through each half of the winding (field aiding); coils produced a MF in the horizontal direction at the center of the system
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.2 mT effective value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The amount of reactive oxygen species was not significantly different between the exposure and sham exposure group. However, lipid peroxidation and the superoxide dismutase enzyme activity were significantly increased in the exposure group compared to the sham exposure group.
The authors conclude that exposure of mice to a 60 Hz magnetic field could cause oxidative stress and deteriorate the antioxidative defense in the brain.

Study character:

Study funded by

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