Study type: Medical/biological study (experimental study)

Zinc supplementation ameliorates electromagnetic field-induced lipid peroxidation in the rat brain. med./bio.

Published in: Tohoku J Exp Med 2006; 208 (2): 133-140

Aim of study (acc. to author)

To study the effects of electromagnetic field exposure and zinc administration on lipid peroxidation in the rat brain.

Background/further details

Some of possible adverse health effects of electromagnetic field exposure are lipid peroxidation and cell damage in various tissues.
24 male were randomly divided into three groups: 1) untreated for 6 months (control, n = 8), 2) exposed to low frequency (50 Hz) electromagnetic fields for 5 minutes every other day for 6 months (n = 8), or 3) exposed to electromagnetic fields and daily zinc sulfate administration (3 mg/kg/day) (n = 8).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 5 min exposure on every other day for 6 months

General information

Rats were divided into three groups (n=8/group): 1) Sham exposure group, 2) 50 Hz exposure group and 3) 50 Hz exposure + 3 mg/kg/day zinc sulfate.

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 5 min exposure on every other day for 6 months
Exposure setup
Exposure source
Setup single coil wrapped around the plastic cage (35 x 25 x 25 cm)
Sham exposure A sham exposure was conducted.
Additional info Rats in one of the group received a daily intraperitoneal injection of 3 mg/kg zinc sulfate in isotonic saline solution of less than 0.5 ml for 6 months.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 5 µT unspecified calibration - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

TBARS levels were higher (both in plasma and brain tissues) in electromagnetic field-exposed rats with or without zinc supplementation, than those in controls. Additionally, TBARS levels were significantly lower in the zinc-supplemented animals than those in the electromagnetic field-exposed rats.
Glutathione levels were significantly decreased in electromagnetic field exposed rats, and were highest in the zinc-supplemented animals.
Plasma zinc was significantly lower in the electromagnetic field-exposed animals than those in controls, while it was highest in the zinc-supplemented rats.
The data suggest that long-term exposure to low frequency electromagnetic field increases lipid peroxidation in the brain, which may be ameliorated by zinc supplementation.

Study character:

Study funded by

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