EMF-Portal | Expression of the immediate early gene, c-fos, in mouse brain after acute global system for mobile communication microwave exposure

Expression of the immediate early gene, c-fos, in mouse brain after acute global system for mobile communication microwave exposure med./bio.

Aim of study (acc. to author)

Endpoint

Exposure

microwaves

mobile communications
GSM

Exposure	Parameters
Exposure 1: 900 MHz Modulation type: pulsed Exposure duration: continuous for 60 min	SAR: 4 W/kg average over mass (whole body)

Exposure 1

Main characteristics

Frequency	900 MHz
Type	electromagnetic field
Charakteristic	far field
Exposure duration	continuous for 60 min

Modulation

Modulation type	pulsed
Pulse width	0.6 ms
Repetition frequency	217 Hz

Exposure setup

Exposure source	dipole antenna
Setup	Exposure modules (with well-defined dosimetry) consisted of a cylindrical parallel plate with mice restrained in ventilated clear Perspex tubes arranged around the antenna.
Additional info	Three groups of mice were used: exposed, sham-exposed and control mice without handling or further restraint.

Parameters

Measurand	Value	Type	Method	Mass	Remarks
SAR	4 W/kg	average over mass	unspecified	whole body	-

Reference articles

Finnie JW et al. (2001): Effect of global system for mobile communication (gsm)-like radiofrequency fields on vascular permeability in mouse brain

Exposed system:

animal
mouse/C57BL/6NTac
whole body

Methods Endpoint/measurement parameters/methodology

Investigated system:

tissue slices

Investigated organ system:

brain/CNS

Time of investigation:

after exposure

Main outcome of study (acc. to author)

Activation of c-fos in the brains of exposed and sham-exposed mice was comparable, but it was greatly increased compared to brains of freely moving control animals. These data indicate that the majority of the acute genomic response detected by c-fos expression was due to immobilisation rather than irradiation.

Study character:

medical/biological study
experimental study
full/main study

Study funded by

not stated/no funding

Orendacova J et al. (2011): Effects of short-duration electromagnetic radiation on early postnatal neurogenesis in rats: Fos and NADPH-d histochemical studies

Jorge-Mora T et al. (2011): The Effects of Single and Repeated Exposure to 2.45 GHz Radiofrequency Fields on c-Fos Protein Expression in the Paraventricular Nucleus of Rat Hypothalamus

Lopez-Martin E et al. (2009): The action of pulse-modulated GSM radiation increases regional changes in brain activity and c-Fos expression in cortical and subcortical areas in a rat model of picrotoxin-induced seizure proneness

Zhao R et al. (2007): Studying gene expression profile of rat neuron exposed to 1800 MHz radiofrequency electromagnetic fields with cDNA microassay

Finnie JW et al. (2007): Stress response in mouse brain after long-term (2 year) exposure to mobile telephone radiofrequency fields using the immediate early gene, c-fos

Finnie JW et al. (2006): Expression of the immediate early gene, c-fos, in fetal brain after whole of gestation exposure of pregnant mice to global system for mobile communication microwaves