Study type: Medical/biological study (experimental study)

Frequency of micronuclei in the peripheral blood and bone marrow of cancer-prone mice chronically exposed to 2450 MHz radiofrequency radiation. med./bio.

Published in: Radiat Res 1997; 147 (4): 495-500

Aim of study (acc. to author)

To assess the extent of cytogenetic damage (assessed by micronucleus assay) in peripheral blood and bone marrow cells of cancer-prone mice that were exposed chronically to 2450 MHz radiofrequency radiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2,450 MHz
Modulation type: CW
Exposure duration: repeated daily exposure, 20 h/day, for 18 months
  • SAR: 1 W/kg average over mass (whole body)

Exposure 1

Main characteristics
Frequency 2,450 MHz
Type
Charakteristic
  • guided field
Polarization
  • circular
Exposure duration repeated daily exposure, 20 h/day, for 18 months
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber one Plexiglas cage per waveguide housing two mice with 143 cm² floor area per mouse
Sham exposure A sham exposure was conducted.
Additional info Animals were divided into two groups of 100 each that were RF or sham exposed. Surviving sentinel mice were treated i.p. with MMC as a positive control 24 h before necropsy.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1 W/kg average over mass measured whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Chronic low-level exposure of C3H/HeJ mice to 2450 MHz radiofrequency radiation did not demonstrate any genotoxicity. The results indicate that the incidence of micronuclei was not significantly different between the exposed and the sham-exposed groups. Mammary tumors were recorded in 12 of the 62 mice exposed to radiofrequency radiation and 8 of the 58 sham-exposed control mice.

Study character:

Study funded by

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