Study type: Medical/biological study (experimental study)

Induction of adaptive response in mice exposed to 900MHz radiofrequency fields: application of micronucleus assay. med./bio.

Published in: Mutat Res Genet Toxicol Environ Mutagen 2013; 751 (2): 127-129

Aim of study (acc. to author)

To evaluate the extent of a DNA damage in peripheral blood erythrocytes in mice pre-exposed to 900 MHz radiofrequency (as adaptive dose) and then subjected to 3 Gy gamma radiation (as challenge dose).

Background/further details

Adaptive response: It is known that different cell types that were exposed to an extremely small adaptation dose of a genotoxic agent are less susceptible to the induction of a genetic damage when given a higher challenge dose of the same or similar genotoxic agent.
Mice were divided into 6 groups (n=10 per group): 1.) control group, 2.) gamma radiation alone (3 Gy, dose rate 0.5 Gy/min), 3.) radiofrequency exposure, 4.) radiofrequency exposure + gamma radiation, 5.) sham exposure and 6.) sham exposure + gamma radiation. Mice were sacrificed 72 hours after the last treatment to collect blood and bone marrow.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: CW
Exposure duration: 4 h/day for 7 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration 4 h/day for 7 days
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber each mouse was exposed individually in a small plastic box, placed on a non-conductive platform
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power density 120 µW/cm² - - - -
SAR 548 mW/kg - calculated whole body -

Reference articles

  • Cao Y et al. (2011): Induction of adaptive response: pre-exposure of mice to 900 MHz radiofrequency fields reduces hematopoietic damage caused by subsequent exposure to ionising radiation.
  • Cao Y et al. (2010): Effects of 900-MHz Microwave Radiation on gamma-Ray-Induced Damage to Mouse Hematopoietic System.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Combined exposures to radiofrequency and gamma radiation yielded in a significant decrease in the number of micronuclei in erythrocytes and bone marrow cells when compared to gamma radiated mice alone, whereas no such an effect was observed in sham exposed and gamma radiated mice.
The data indicate that there is a radiofrequency induced adaptive response in mice. Hence, pre-exposure to radiofrequency fields could be capable to protect the erythrocytes and bone marrow cells from genotoxic effects of a subsequent gamma radiation.

Study character:

Study funded by

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