Study type: Medical/biological study (experimental study)

Alteration of nitric oxide production in rats exposed to a prolonged, extremely low-frequency magnetic field. med./bio.

Published in: Electromagn Biol Med 2007; 26 (2): 99-106

Aim of study (acc. to author)

The purpose of this in vivo study was to investigate the possible effects of extremely low-frequency magnetic fields on nitric oxide (NO) level in rats.

Background/further details

Twenty-seven male, four months old rats were used. Animals were exposed to three different magnetic flux densities, on the basis of the magnetic fields exposure limits of ICNIRP (100 μT: general public limit, 500 μT: occupational limit).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 2 h/day for 10 months
Exposure 2: 50 Hz
Exposure duration: 2 h/day for 10 months

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 2 h/day for 10 months
Exposure setup
Exposure source
Setup pair of Helmholtz coils with a diameter of 25 cm with 225 turns of 1 mm insulated copper wire, 25 cm apart, in a 130 cm x 65 cm x 80 cm Faraday cage; rats in 17 cm x 17 cm x 25 cm methacrylate boxes between the coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT - measured - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Exposure duration 2 h/day for 10 months
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 500 µT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A significant reduction was observed in nitrite levels among the extremely low frequency exposure groups (100 μT and 500 μT) of rats compared to sham exposed rats after exposure for 10 months.

Study character:

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