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Medical/biological study (experimental study)

Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum.

Published in: Gen Physiol Biophys 2011; 30 (4): 415-421

Aim of study (acc. to author)

To study whether an extremely low frequency magnetic field induces lipid peroxidation and reactive oxygen species in mouse cerebellum.
Background/further details: 20 mice were divided into an exposure group and a sham exposure group (each group n=10).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: three hours
Exposure 1
Main characteristics
Frequency 60 Hz
Type
Exposure duration three hours
Exposure setup
Setup mice were kept inside their cages during exposure
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2.3 mT - - - -
Exposed system:
  • animal
  • mouse/BALB/c
  • whole body

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

After exposure to the 60 Hz extremely low frequency magnetic field at 2.3 mT for three hours, there was a significant increase in malondialdehyde and hydroxyl radical levels. Exposure significantly induced concomitant increase in superoxide dismutase enzyme activity without alteration in glutathione peroxidase enzyme activity. While glutathione contents were not altered, ascorbic acid level was significantly decreased by extremely low frequency magnetic field exposure.
These results indicate that the extremely low frequency magnetic field may induce oxidative stress in mouse cerebellum.
Study character:

Study funded by

  • Korea Research Foundation (KRF), Korea
  • Ministry of Education and Human Resources Development, Korea

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