1) To study wether 50 Hz electric fields (12 kV/m) induce nitrosative stress and oxidative stress in guinea pigs lung tissue
2) To study the possible effects of extremely low frequency electric fields on collagen synthesis.
Additionally, the effects of antioxidant treatment such as epigallocatechin-3-gallate and N-acetyl-L-cysteine were investigated.
60 guinea pigs were divided into six groups: 1) control group (with saline injection), 2) epigallocatechin-3-gallate injection alone, 3) N-acetyl-L-cysteine injection alone, 4) saline injection before exposure, 5) epigallocatechin-3-gallate injection before exposure, and 6) N-acetyl-L-cysteine before exposure.
Exposure duration: 8 h/day for 7 days
|Exposure duration||8 h/day for 7 days|
|electric field strength||12 kV/m||-||measured and calculated||-||-|
While protein carbonyl content levels significantly increased, insignificant changes were observed in heme oxygenase-1, malondialdehyde, and nitric oxide levels for electric field exposure groups compared to the control group. The data showed no significant changes in these parameters on the electric field group compared to the group where epigallocatechin-3-gallate and N-acetyl-L-cysteine were separately applied along with electric field.