Medical/biological study (experimental study)

Influence of 864 MHz electromagnetic field on growth kinetics of established cell line med./bio.

By: Pavicic I, Trosic I

Published in: Biologia 2006; 61 (3): 321-325

Exposure	Parameters
Exposure 1: 864 MHz Modulation type: CW Exposure duration: continuous for 1, 2 or 3 hr	electric field strength: 7.3 V/m power density: 0.1 W/m² average over mass SAR: 0.08 W/kg average over mass (cf. remarks) (one cell)

Modulation type	CW

Exposure source	TEM cell
Sham exposure	A sham exposure was conducted.

Measurand	Value	Type	Method	Mass	Remarks
electric field strength	7.3 V/m	-	-	-	-
power density	0.1 W/m²	average over mass	-	-	-
SAR	0.08 W/kg	average over mass	calculated	cf. remarks	one cell

Exposed system:

Investigated system:

Time of investigation:

Growth curves of exposed cells showed a significant decrease after 2 and 3 hours of exposure on experimental day 3, respectively, in comparison to sham exposed cells. Both, the colony forming ability and cell viability of exposed cells did not significantly differ from sham exposure condition.
In conclusion, under strictly controlled laboratory conditions, applied radiofrequency irradiation significantly affected cell proliferation kinetics but not cell viability or ability of V79 cells to form colonies.

Study character:

Sekijima M et al. (2010): 2-GHz band CW and W-CDMA modulated radiofrequency fields have no significant effect on cell proliferation and gene expression profile in human cells
Trosic I et al. (2009): Disturbance of cell proliferation in response to mobile phone frequency radiation
Pavicic I et al. (2008): Impact of 864 MHz or 935 MHz radiofrequency microwave radiation on the basic growth parameters of V79 cell line
Pavicic I et al. (2008): In vitro testing of cellular response to ultra high frequency electromagnetic field radiation
Hoyto A et al. (2008): Proliferation, Oxidative Stress and Cell Death in Cells Exposed to 872 MHz Radiofrequency Radiation and Oxidants
Hoyto A et al. (2008): Radiofrequency radiation does not significantly affect ornithine decarboxylase activity, proliferation, or caspase-3 activity of fibroblasts in different physiological conditions
Pavicic I et al. (2006): Comparison of 864 MHz and 935 MHz microwave radiation effects on cell culture
Duranti G et al. (2005): In Vitro Evaluation of Biological Effects on Human Keratinocytes Exposed to 900 MHz Electromagnetic Field
Pacini S et al. (2002): Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts
French PW et al. (1997): Electromagnetic radiation at 835 MHz changes the morphology and inhibits proliferation of a human astrocytoma cell line