Study type: Medical/biological study (experimental study)

Exposure to global system for mobile communication (GSM) cellular phone radiofrequency alters gene expression, proliferation, and morphology of human skin fibroblasts. med./bio.

Published in: Oncol Res 2002; 13 (1): 19-24

Aim of study (acc. to author)

To study the effects of GSM radiofrequency exposure in human skin fibroblasts. Changes in cell morphology and gene expression were evaluated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 902.4 MHz
Modulation type: pulsed
Exposure duration: continuous for 1 h

Exposure 1

Main characteristics
Frequency 902.4 MHz
Type
Exposure duration continuous for 1 h
Modulation
Modulation type pulsed
Exposure setup
Exposure source
Chamber Exposed and sham exposed cell cultures were placed in ordinary reading rooms of 26°C and 60% humidity, whereas control plates were kept inside an incubator of 37°C, 95% humidity and 5% CO2.
Setup Six-well culture plates were placed above the cellular phone switched on the answering mode, in communication with a second phone located close to a voice source in a distant room.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 10 V/m maximum measured - 9-10 V/m at 1 cm
power density 1 W/m² maximum measured - -
SAR 0.6 W/kg mean unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Exposure of cultured human cells to cellular phone radiofrequencies caused morphological changes and increased the expression of mitogenic signal transduction genes, cell growth inhibitors, and genes controlling apoptosis.The increase in DNA synthesis matched the rise in diacylglycerol, the second messenger, that induces the expression of mitogen-activated protein (MAP) kinase family genes.
The data showed that exposure of cultured cells to mobile phone radiofrequencies caused morphological and functional changes.

Study character:

Study funded by

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