Study type: Medical/biological study (experimental study)

The effects of electromagnetic fields on peripheral blood mononuclear cells in vitro. med./bio.

Published in: Bratisl Lek Listy 2009; 110 (9): 526-529

Aim of study (acc. to author)

To study the changes in the cell viability, rates of apoptosis, proliferation index and the cell surface antigenic structures resulting from 2 h-, 6 h- and 24 h-exposure of mononuclear cells isolated from the peripheral blood of five healthy donors to 450 MHz, 900 MHz and 1784 MHz electromagnetic fields.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 450 MHz
Exposure duration: continuous for 2 hr, 6 hr or 24 hr
Exposure 2: 900 MHz
Exposure duration: continuous for 2 hr, 6 hr or 24 hr
Exposure 3: 1,784 MHz
Exposure duration: continuous for 2 hr, 6 hr or 24 hr

Exposure 1

Main characteristics
Frequency 450 MHz
Type
Exposure duration continuous for 2 hr, 6 hr or 24 hr
Exposure setup
Exposure source
Setup antenna with an aperture angle of 60° and a gain of 9 - 11 dB placed inside an incubator
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 30 V/m - measured - -

Exposure 2

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 2 hr, 6 hr or 24 hr
Exposure setup
Exposure source
Setup antenna with an aperture angle of 60° and a gain of 9 - 11 dB placed inside an incubator
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 48.3 V/m - measured - -

Exposure 3

Main characteristics
Frequency 1,784 MHz
Type
Exposure duration continuous for 2 hr, 6 hr or 24 hr
Exposure setup
Exposure source
Setup antenna with an aperture angle of 60° and a gain of 9 - 11 dB placed inside an incubator
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 53 V/m - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that the electromagnetic field exposures did not have any effect on the cell viability, rates of apoptosis and the proliferation index. While electromagnetic field exposures did not affect the major histocompatibility complex class II and CD11b expressions in the peripheral blood mononuclear cells, they decreased the CD11a expression and increased the CD49d expression.
In conclusion, these findings suggest that electromagnetic fields could affect the functional capacity of the peripheral blood mononuclear cells by changing their adhesion ability.

Study character:

Study funded by

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