Study type: Medical/biological study (experimental study)

Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes med./bio.

Published in: Radiat Res 2008; 170 (3): 327-334

Aim of study (acc. to author)

The induction of apoptosis after a 1h exposure to 900 MHz radiofrequency radiation (GSM signal) was investigated in proliferating human lymphocytes and lymphocytes in G0-Phase.

Background/further details

The mean specific absorption rate value used for the exposure was higher than the International Commission on Non-Ionizing Radiation Protection (ICNIRP) reference for safety limits. All experiments were repeated at least three times. Cells treated with Fas ligand and cytarabine served as positive controls.



Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 1 h
  • SAR: 1.35 W/kg spatial average
  • SAR: 10.8 W/kg peak value

Exposure 1

Main characteristics
Frequency 900 MHz
Exposure duration continuous for 1 h
Exposure setup
Exposure source
Setup wire patch cell located inside a CO2 incubator, shielded through metal grid boxes and absorbers
Sham exposure A sham exposure was conducted.
Measurand Value Type Method Mass Remarks
SAR 1.35 W/kg spatial average measured and calculated - -
SAR 10.8 W/kg peak value measured and calculated - -

Reference articles

  • Scarfi MR et al. (2006): Exposure to radiofrequency radiation (900 MHz, GSM signal) does not affect micronucleus frequency and cell proliferation in human peripheral blood lymphocytes: an interlaboratory study
  • Merola P et al. (2006): Proliferation and apoptosis in a neuroblastoma cell line exposed to 900 MHz modulated radiofrequency field
  • Laval L et al. (2000): A new in vitro exposure device for the mobile frequency of 900 MHz

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A slight but statistically significant increase in caspase 3 activity, measured 6 h after exposure, was observed in Jurkat cells and in proliferating human peripheral blood lymphocytes, but not in human peripheral blood lymphocytes cells in G0-phase.
No changes after radiofrequency exposure have been observed in apoptosis, cell cycle progression and cell viability.

Study character:

Study funded by

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