Study type: Medical/biological study (experimental study)

Exposure to 900 MHz radiofrequency radiation induces caspase 3 activation in proliferating human lymphocytes. med./bio.

Published in: Radiat Res 2008; 170 (3): 327-334

Aim of study (acc. to author)

The induction of apoptosis after a 1h exposure to 900 MHz radiofrequency radiation (GSM signal) was investigated in proliferating human lymphocytes and lymphocytes in G0-Phase.

Background/further details

The mean specific absorption rate value used for the exposure was higher than the International Commission on Non-Ionizing Radiation Protection (ICNIRP) reference for safety limits. All experiments were repeated at least three times. Cells treated with Fas ligand and cytarabine served as positive controls.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 1 h
  • SAR: 1.35 W/kg spatial average
  • SAR: 10.8 W/kg peak value

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 1 h
Exposure setup
Exposure source
Setup wire patch cell located inside a CO2 incubator, shielded through metal grid boxes and absorbers
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.35 W/kg spatial average measured and calculated - -
SAR 10.8 W/kg peak value measured and calculated - -

Reference articles

  • Scarfi MR et al. (2006): Exposure to radiofrequency radiation (900 MHz, GSM signal) does not affect micronucleus frequency and cell proliferation in human peripheral blood lymphocytes: an interlaboratory study.
  • Merola P et al. (2006): Proliferation and apoptosis in a neuroblastoma cell line exposed to 900 MHz modulated radiofrequency field.
  • Laval L et al. (2000): A new in vitro exposure device for the mobile frequency of 900 MHz.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A slight but statistically significant increase in caspase 3 activity, measured 6 h after exposure, was observed in Jurkat cells and in proliferating human peripheral blood lymphocytes, but not in human peripheral blood lymphocytes cells in G0-phase.
No changes after radiofrequency exposure have been observed in apoptosis, cell cycle progression and cell viability.

Study character:

Study funded by

Related articles