Study type: Medical/biological study (experimental study)

Mutagenic response of 2.45 GHz radiation exposure on rat brain med./bio.

Published in: Int J Radiat Biol 2010; 86 (4): 334-343

Aim of study (acc. to author)

To investigate the effect of 2.45 GHz microwave exposure on developing rat brain (35 days old).

Background/further details

Six rats were exposed and six rats were sham-exposed.



Exposure Parameters
Exposure 1: 2.45 GHz
Exposure duration: continuous for 2 hr/day on 35 days

Exposure 1

Main characteristics
Frequency 2.45 GHz
Exposure duration continuous for 2 hr/day on 35 days
Exposure setup
Exposure source
Setup 48 cm x 27 cm x 15 cm ventilated plastic cage placed inside a temperature-controlled anechoic chamber lined with RF absorbing material; microwave oven connected to horn antenna; aperture of horn antenna facing the cage
Sham exposure A sham exposure was conducted.
Measurand Value Type Method Mass Remarks
power 1,080 W - - - input power
power 700 W - measured - output power
power density 0.34 mW/cm² - - - -
SAR 0.11 W/kg - estimated whole body -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A significant increase was observed in different parameters of comet assay (e.g. comet head length, tail length) in exposed brain cells. An analysis of antioxidant enzymes glutathione peroxidase and superoxide dismutase showed a decrease in enzyme activities under exposure while an increase in catalase enzyme activity was found. A significant decrease in histone kinase enzyme activity was also recorded in the exposed group as compared to the sham exposed ones.
The authors conclude that the chronic exposure to 2.45 GHz microwaves may cause a significant damage to the brain, which may be an indication of possible tumour promotion.

Study character:

Study funded by

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