Evaluation of genotoxic effects in male Wistar rats following microwave exposure med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• micronuclei formation, reactive oxygen species production and antioxidant defense

Exposure

• • 10–50 GHz
  • microwaves
  • millimeter waves

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• genotoxicity/mutation: micronuclei formation in polychromatic erythrocytes and normochromatic erythrocytes (acridine orange staining; flow cytometry)
• molecular biosynthesis: serum reactive oxygen species production (spectrophotometry)
• cell function: antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase and catalase; spectrophotometry)

Main outcome of study (acc. to author)

Study funded by

• Council of Scientific and Industrial Research (CSIR), New Delhi, India
• Indian Council of Medical Research (ICMR), India

Related articles

• Trosic I et al. (2011): Effect of electromagnetic radiofrequency radiation on the rats' brain, liver and kidney cells measured by comet assay
• Luukkonen J et al. (2010): Combined effects of 872 MHz radiofrequency radiation and ferrous chloride on reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells
• Kesari KK et al. (2010): Mutagenic response of 2.45 GHz radiation exposure on rat brain
• Gurbuz N et al. (2010): Is There Any Possible Genotoxic Effect in Exfoliated Bladder Cells of Rat Under the Exposure of 1800 MHz GSM-Like Modulated Radio Frequency Radiation (RFR)?
• Kesari KK et al. (2009): Fifty-gigahertz microwave exposure effect of radiations on rat brain
• Luukkonen J et al. (2009): Enhancement of chemically induced reactive oxygen species production and DNA damage in human SH-SY5Y neuroblastoma cells by 872 MHz radiofrequency radiation
• Ziemann C et al. (2009): Absence of genotoxic potential of 902 MHz (GSM) and 1747 MHz (DCS) wireless communication signals: In vivo two-year bioassay in B6C3F1 mice
• Yao K et al. (2008): Electromagnetic noise inhibits radiofrequency radiation-induced DNA damage and reactive oxygen species increase in human lens epithelial cells
• Elhag MA et al. (2007): Effects of electromagnetic field produced by mobile phones on the oxidant and antioxidant status of rats
• Belyaev IY et al. (2006): Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation
• Yurekli AI et al. (2006): GSM base station electromagnetic radiation and oxidative stress in rats
• Ferreira AR et al. (2006): Ultra high frequency-electromagnetic field irradiation during pregnancy leads to an increase in erythrocytes micronuclei incidence in rat offspring
• Gorlitz BD et al. (2005): Effects of 1-week and 6-week exposure to GSM/DCS radiofrequency radiation on micronucleus formation in B6C3F1 mice
• Vijayalaxmi et al. (2003): Genotoxic potential of 1.6 GHz wireless communication signal: in vivo two-year bioassay
• Zotti-Martelli L et al. (2000): Induction of micronuclei in human lymphocytes exposed in vitro to microwave radiation