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To study whether real mobile phone exposure affects the object recognition memory in mice. The objects consisted of cubes, pyramides and cylinders of different colours.
The object recognition task consists of a habituation session (day 1), a training session (acquisition phase with two identical objects; day 2) and a test session (day 3). Day 3 consists of two trials (one trial with familiar objects and one trial with a familiar and a novel object) and an inter-trial interval (for memory consolidation).
Mice were divided into three groups (8 animals per group: exposed, sham exposed and control) and the object recognition task was performed according to the following three protocols: 1) "acute exposure": mice (45 days old) were exposed to the mobile phone during the habituation, the training and the test sessions, but not during the 10 min inter-trial interval (memory consolidation phase); 2) "chronic exposure-I": the same mice were exposed for 17 days for 90 min/per day starting at postnatal day 55 to the same mobile phone irradiation. The object recognition task was performed at postnatal day 72 with irradiation present only during the inter-trial interval phase; 3) "chronic exposure-II": mice were continuously exposed daily under the same conditions up to postnatal day 86 (total exposure duration: 31 days). One day later the object recognition task test was performed without irradiation.
|ばく露時間||90 min/day for 3 days (acute exposure), 17 days (chronic exposure-I) or 31 days (chronic exposure-II)|
|チャンバの詳細||sound proof, air-conditioned room|
|ばく露装置の詳細||8 animals kept in a 267 mm x 207 mm x 140 mm Plexiglas cage placed in a half-open Faraday cage; mobile phone placed under the cage or the ORT (object recognition test) apparatus; radio playing during exposure to simulate human voice during mobile phone use|
|Sham exposure||A sham exposure was conducted.|
The data revealed a major effect of the "chronic exposure-I" suggesting a possible severe effect of the electromagnetic field on the memory consolidation phase of the recognition memory process. This may imply that the primary electromagnetic field target may be the entorhinal-hippocampal regions which participate in the object recognition.