研究のタイプ: 医学/生物学の研究 (experimental study)

[マウスの短期記憶は携帯電話放射による影響を受ける] med./bio.

Short-term memory in mice is affected by mobile phone radiation.

掲載誌: Pathophysiology 2011; 18 (3): 193-199

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研究目的(著者による)

To study whether real mobile phone exposure affects the object recognition memory in mice. The objects consisted of cubes, pyramides and cylinders of different colours.

詳細情報

The object recognition task consists of a habituation session (day 1), a training session (acquisition phase with two identical objects; day 2) and a test session (day 3). Day 3 consists of two trials (one trial with familiar objects and one trial with a familiar and a novel object) and an inter-trial interval (for memory consolidation).
Mice were divided into three groups (8 animals per group: exposed, sham exposed and control) and the object recognition task was performed according to the following three protocols: 1) "acute exposure": mice (45 days old) were exposed to the mobile phone during the habituation, the training and the test sessions, but not during the 10 min inter-trial interval (memory consolidation phase); 2) "chronic exposure-I": the same mice were exposed for 17 days for 90 min/per day starting at postnatal day 55 to the same mobile phone irradiation. The object recognition task was performed at postnatal day 72 with irradiation present only during the inter-trial interval phase; 3) "chronic exposure-II": mice were continuously exposed daily under the same conditions up to postnatal day 86 (total exposure duration: 31 days). One day later the object recognition task test was performed without irradiation.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,800 MHz
ばく露時間: 90 min/day for 3 days (acute exposure), 17 days (chronic exposure-I) or 31 days (chronic exposure-II)
  • 電界強度: 17 V/m average over time (averaged over 6 min)
  • SAR: 0.22 W/kg average over mass (brain)

ばく露1

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 90 min/day for 3 days (acute exposure), 17 days (chronic exposure-I) or 31 days (chronic exposure-II)
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
チャンバの詳細 sound proof, air-conditioned room
ばく露装置の詳細 8 animals kept in a 267 mm x 207 mm x 140 mm Plexiglas cage placed in a half-open Faraday cage; mobile phone placed under the cage or the ORT (object recognition test) apparatus; radio playing during exposure to simulate human voice during mobile phone use
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 17 V/m average over time 測定値 - averaged over 6 min
SAR 0.22 W/kg average over mass 計算値 brain -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The data revealed a major effect of the "chronic exposure-I" suggesting a possible severe effect of the electromagnetic field on the memory consolidation phase of the recognition memory process. This may imply that the primary electromagnetic field target may be the entorhinal-hippocampal regions which participate in the object recognition.

研究の種別:

研究助成

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