Study type: Medical/biological study (experimental study)

Lymphoma development of simultaneously combined exposure to two radiofrequency signals in AKR/J mice. med./bio.

Published in: Bioelectromagnetics 2011; 32 (6): 485-492

Aim of study (acc. to author)

To study the effects of combined exposure to CDMA and WCDMA radiofrequency electromagnetic fields on lymphoma development in a lymphoma mouse model.

Background/further details

160 mice (80 male and 80 female) were divided into four groups (each group n=40): 1) male mice, sham exposed, 2) male mice, exposed, 3) female mice, sham exposed, 4) female mice, exposed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 848.5–1,950 MHz
Exposure duration: continuous for 45 min/day, 5 days/week for up to 42 weeks

General information

Mice were treated in four groups: i) male, sham exposed ii) male, exposed iii) female, sham exposed iv) female, exposed

Exposure 1

Main characteristics
Frequency 848.5–1,950 MHz
Type
Exposure duration continuous for 45 min/day, 5 days/week for up to 42 weeks
Additional info f = 848.5 MHz with a channel bandwidth of 1.23 MHz for the CDMA signal f= 1950 MHz with a channel bandwith of 5 MHz for the WCDMA signal both signals applied simultaneously
Exposure setup
Exposure source
Chamber 2.29 m x 2.29 m x 1.47 m reverberation chamber, 2.3 mm thickness of wall
Setup 215 mm x 320 mm x 130 mm cages placed on a 1.32 m x 1.32 m x 0.7 m wooden table inside the chamber; 5 mice per cage
Sham exposure A sham exposure was conducted.
Additional info the article contains unclear information on the number of cages exposed simultaneously (4 or 8)
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 1 V/m effective value measured - -
power 30 W - - - for the CDMA signal
power 18 W - - - for the WCDMA signal
SAR 2 W/kg - calculated - for the WCDMA signal
SAR 2 W/kg - calculated - for the CDMA signal

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No differences were found in final survival, lymphoma incidence, and splenomegaly incidence between sham exposed and radiofrequency exposed mice. However, occurrence of metastasis infiltration to the brain in lymphoma-bearing mice was significantly different in radiofrequency exposed mice when compared to sham exposed mice, even though no consistent correlation was observed between male and female mice (increase in female mice, but decrease in male mice). However, infiltration occurrence to liver, lung, and spleen was not different between the groups.
The authors conclude that simultaneous exposure to CDMA and WCDMA radiofrequency electromagnetic fields did not affect lymphoma development in AKR/J mice.

Study character:

Study funded by

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