研究のタイプ: 医学/生物学の研究 (experimental study)

[2種類のRF信号の組み合わせへの同時ばく露によるAKR/Jマウスでのリンパ腫発症] med./bio.

Lymphoma development of simultaneously combined exposure to two radiofrequency signals in AKR/J mice.

掲載誌: Bioelectromagnetics 2011; 32 (6): 485-492

【目的】リンパ腫のモデル動物であるAKR/Jマウスを対象に、RF電磁界信号の組み合わせばく露による発がん性の影響を調べること。【方法】2種類のRF信号(CDMAとWCDMA)を組み合わせて、6週齢AKR/Jマウスに同時ばく露した。組み合わせばく露は45分間/日、5日/週とし、全体で42週間行った。CDMAとWCDMAの電磁界による全身平均比吸収率SAR)はそれぞれ2.0 W/kgとし、合計4.0 W/kg とした。【結果】最終的な生存個体数、リンパ腫発生率脾腫発生率について、RFばく露群と擬似ばく露群の間に差は見られなかった。リンパ腫を発症したマウスにおける脳への浸潤性の転移発生率は両群で有意に異なっていたが、オスとメスで観察された相関関係は一致しなかった(一方は減少、他方は増加を示した)。肝臓、肺、脾臓への浸潤発生率にはばく露擬似ばく露間で差がなかった。【結論】CDMA とWCDMAの電磁界への同時ばく露はAKR/Jマウスにおけるリンパ腫発症に影響しなかった。

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研究目的(著者による)

To study the effects of combined exposure to CDMA and WCDMA radiofrequency electromagnetic fields on lymphoma development in a lymphoma mouse model.

詳細情報

160 mice (80 male and 80 female) were divided into four groups (each group n=40): 1) male mice, sham exposed, 2) male mice, exposed, 3) female mice, sham exposed, 4) female mice, exposed.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 848.5–1,950 MHz
ばく露時間: continuous for 45 min/day, 5 days/week for up to 42 weeks
  • 電界強度: 1 V/m effective value
  • 電力: 30 W (for the CDMA signal)
  • 電力: 18 W (for the WCDMA signal)
  • SAR: 2 W/kg (for the WCDMA signal)
  • SAR: 2 W/kg (for the CDMA signal)

General information

Mice were treated in four groups: i) male, sham exposed ii) male, exposed iii) female, sham exposed iv) female, exposed

ばく露1

主たる特性
周波数 848.5–1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 45 min/day, 5 days/week for up to 42 weeks
Additional information f = 848.5 MHz with a channel bandwidth of 1.23 MHz for the CDMA signal f= 1950 MHz with a channel bandwith of 5 MHz for the WCDMA signal both signals applied simultaneously
ばく露装置
ばく露の発生源/構造
  • patch antenna
チャンバの詳細 2.29 m x 2.29 m x 1.47 m reverberation chamber, 2.3 mm thickness of wall
ばく露装置の詳細 215 mm x 320 mm x 130 mm cages placed on a 1.32 m x 1.32 m x 0.7 m wooden table inside the chamber; 5 mice per cage
Sham exposure A sham exposure was conducted.
Additional information the article contains unclear information on the number of cages exposed simultaneously (4 or 8)
パラメータ
測定量 種別 Method Mass 備考
電界強度 1 V/m effective value 測定値 - -
電力 30 W - - - for the CDMA signal
電力 18 W - - - for the WCDMA signal
SAR 2 W/kg - 計算値 - for the WCDMA signal
SAR 2 W/kg - 計算値 - for the CDMA signal

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

No differences were found in final survival, lymphoma incidence, and splenomegaly incidence between sham exposed and radiofrequency exposed mice. However, occurrence of metastasis infiltration to the brain in lymphoma-bearing mice was significantly different in radiofrequency exposed mice when compared to sham exposed mice, even though no consistent correlation was observed between male and female mice (increase in female mice, but decrease in male mice). However, infiltration occurrence to liver, lung, and spleen was not different between the groups.
The authors conclude that simultaneous exposure to CDMA and WCDMA radiofrequency electromagnetic fields did not affect lymphoma development in AKR/J mice.

研究の種別:

研究助成

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