Brain hsp70 expression and DNA damage in mice exposed to extremely low frequency magnetic fields: a dose-response study. med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• genotoxicity/mutation: DNA damage
• molecular biosynthesis: expression of Hsp70

Exposure

• • 50/60 Hz
  • magnetic field

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• genotoxicity/mutation: DNA damage (comet assay)
• molecular biosynthesis: expression of Hsp70 (real-time RT-PCR, Western blot)
• food intake, body weight

Main outcome of study (acc. to author)

Study funded by

• Fondazione Cassa di Risparmio di Perugia, Italy
• University of Perugia, Italy

Related articles

• Wang Y et al. (2019): Exposure to a 50 Hz magnetic field at 100 µT exerts no DNA damage in cardiomyocytes.
• Woodbine L et al. (2015): The rate of X-ray induced DNA double strand break repair in the embryonic mouse brain is unaffected by exposure to 50 Hz magnetic fields.
• Saha S et al. (2014): Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields.
• Rodriguez-De la Fuente AO et al. (2012): Effect of 60 Hz electromagnetic fields on the activity of hsp70 promoter: an in vivo study.
• Mariucci G et al. (2010): Brain DNA damage and 70-kDa heat shock protein expression in CD1 mice exposed to extremely low frequency magnetic fields.
• Vijayalaxmi et al. (2009): Genetic damage in mammalian somatic cells exposed to extremely low frequency electro-magnetic fields: a meta-analysis of data from 87 publications (1990-2007).
• George I et al. (2008): Myocardial function improved by electromagnetic field induction of stress protein hsp70.
• McNamee JP et al. (2005): Evaluating DNA damage in rodent brain after acute 60 Hz magnetic-field exposure.
• Schmitz C et al. (2004): 50-Hz magnetic field exposure influences DNA repair and mitochondrial DNA synthesis of distinct cell types in brain and kidney of adult mice.
• Lai H et al. (2004): Magnetic-field-induced DNA strand breaks in brain cells of the rat.
• McNamee JP et al. (2002): DNA damage and apoptosis in the immature mouse cerebellum after acute exposure to a 1 mT, 60 Hz magnetic field.
• Svedenstal BM et al. (1999): DNA damage induced in brain cells of CBA mice exposed to magnetic fields.
• Svedenstal BM et al. (1999): DNA damage, cell kinetics and ODC activities studied in CBA mice exposed to electromagnetic fields generated by transmission lines.
• Singh N et al. (1998): 60 Hz magnetic field exposure induces DNA crosslinks in rat brain cells.
• Lai H et al. (1997): Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells.
• Lai H et al. (1997): Melatonin and N-tert-butyl-alpha-phenylnitrone block 60-Hz magnetic field-induced DNA single and double strand breaks in rat brain cells.