Study type: Medical/biological study (experimental study)

DNA damage, cell kinetics and ODC activities studied in CBA mice exposed to electromagnetic fields generated by transmission lines. med./bio.

Published in: In Vivo 1999; 13 (6): 507-513

Aim of study (acc. to author)

To investigate the effects of electromagnetic fields on mice. Possible genotoxic effects, effects on body weight, erythrocytes, leukocytes, as well as ornithine decarboxylase (ODC) activity in spleen and testis were investigated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 11 days, 20 days or 32 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 11 days, 20 days or 32 days
Exposure setup
Exposure source
Setup Animals were placed in plastic cages with special lids to prevent eddy currents. The cages were placed in wooden boxes which were placed below the lines
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 8 µT effective value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

If all exposed animals were pooled together, the body weight was found to be statisticaly significant lower at the end of exposure compared with unexposed mice. However, no significant alteration of body weight was seen when each exposed group (11, 20, and 32 days) were examined individually. After 32 days of exposure only spleen weight was found to be statisicaly lower as compared with sham exposed animals.
After 20 days of EMF-exposure a decreased number of mononuclear leukocytes were found. Exposure for 32 days leads to a clear DNA-damage. Overall the ODC activity was not altered if all exposed animals were pooled together.

Study character:

Study funded by

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