Study type: Medical/biological study (experimental study)

Evaluating DNA damage in rodent brain after acute 60 Hz magnetic-field exposure. med./bio.

Published in: Radiat Res 2005; 164 (6): 791-797

Aim of study (acc. to author)

To investigate whether acute magnetic field exposure could elicit DNA damage within brain cells from both whole brain and cerebellar homogenates from adult rats, adult mice, and immature mice.

Background/further details

Adult rats, mice, and immature mice in the positive control group were exposed to X-rays (2 Gy).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous for 2 h

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
  • unspecified
Exposure duration continuous for 2 h
Exposure setup
Exposure source
Chamber Two Quad/4x in vivo magnetic field exposure chambers. Each chamber consisting of 4 x 4 Merritt sets with 40 cm² square coils.
Additional info Sham exposure was performed by configuring the coils in buck mode. Negative (0 Gy X-ray) and positive (2 Gy X-ray) controls were processed with each experimental exposure.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.1 mT - measured - -
magnetic flux density 1 mT - measured - -
magnetic flux density 2 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

For each species, a significant increase in DNA damage was detected by each of the four parameters of the comet assay in the positive control relative to the concurrent non-irradiated negative and sham controls.
However, none of the four parameters detected a significant increase in DNA damage in brain cell homogenates from any magnetic field exposure at any time after exposure. The dose-response and time-course data from the multiple animal groups tested in this study provide no evidence of magnetic field-induced DNA damage.

Study character:

Study funded by

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