Mobile phone use and risk of brain neoplasms and other cancers: prospective study.
Published in: Int J Epidemiol 2013; 42 (3): 792-802
Aim of study (acc. to author)
Endpoint/type of risk estimation
- leukemia and lymphoma: non-Hodgkin lymphoma, myeloma, and leukaemia
- brain tumor: glioma, meningioma, pituitary tumor, acoustic neuroma
- breast cancer
- other head and neck tumors; cancer of oesophagus, stomach, colon, rectum, pancreas, lung, melanoma, cancer of endometrium, ovary, kidney, bladder, eye, and thyroid
Type of risk estimation:
(relative risk (RR))
Reference group 1
mobile phone use: never
mobile phone use: ever
mobile phone use: daily
duration of use: ≥ 10 years
≥ 50 years
women participating in the Million Women Study initiated by the UK National Health Service (NHS) Breast Screening Programme
1996 - 2009, baseline survey on mobile phone use 1999 - 2005, follow-up in 2009
UK National Health Service (NHS) Breast Screening Programme, NHS Central Register, Hospital Episodes Statistics, Scottish Morbidity Records
Statistical analysis method:
- Cox proportional regressions analysis
Conclusion (acc. to author)
During an average of 7 years' follow-up, 51,680 incident invasive cancers and 562 incident non-invasive intracranial CNS tumors occurred among 791,710 middle-aged women.
Risk among women who ever used a mobile phone compared to women who never used a mobile phone was not increased for all intracranial CNS tumors (RR 1.01, CI 0.90-1.14), for specified CNS tumor types nor for cancer at 18 other specified sites. For long-term users compared with never users, there was no appreciable association for glioma (≥ 10 years: RR 0.78, 0.55-1.10) or meningioma (≥ 10 years: RR 1.10, CI 0.66-1.84). For acoustic neuroma, there was an increase in risk with long term use vs never use (≥ years: RR 2.46, CI 1.07-5.64), the risk increasing with duration of use (trend among users, P 0.03). National incidence data showed no overall increase in the incidence of acoustic neuroma in either men or women at ages 20-79 years in England from 1998 to 2008.
The authors concluded that mobile phone use was not associated with increased incidence of glioma, meningioma or non-CNS cancers in this large prospective study.
Study funded by
Medical Research Council, UK
Cancer Research UK
National Health Service Breast Screening Programme, UK
Comments on this article
de Vocht F
The case of acoustic neuroma: Comment on: Mobile phone use and risk of brain neoplasms and other cancers.
Benson VS et al.
Authors' response to: The case of acoustic neuroma: comment on mobile phone use and risk of brain neoplasms and other cancers.