Mobile phone use and risk of brain neoplasms and other cancers: prospective study.
Published in: Int J Epidemiol 2013; 42 (3): 792-802
Aim of study (acc. to author)
Endpoint/type of risk estimation
- leukemia and lymphoma: non-Hodgkin lymphoma, myeloma, and leukaemia
- brain tumor: glioma, meningioma, pituitary tumor, acoustic neuroma
- breast cancer
- other head and neck tumors; cancer of oesophagus, stomach, colon, rectum, pancreas, lung, melanoma, cancer of endometrium, ovary, kidney, bladder, eye, and thyroid
Type of risk estimation:
(relative risk (RR))
Reference group 1
mobile phone use: never
mobile phone use: ever
mobile phone use: daily
duration of use: ≥ 10 years
≥ 50 years
women participating in the Million Women Study initiated by the UK National Health Service (NHS) Breast Screening Programme
1996 - 2009, baseline survey on mobile phone use 1999 - 2005, follow-up in 2009
UK National Health Service (NHS) Breast Screening Programme, NHS Central Register, Hospital Episodes Statistics, Scottish Morbidity Records
Statistical analysis method:
- Cox proportional regressions analysis
Conclusion (acc. to author)
During an average of 7 years' follow-up, 51,680 incident invasive cancers and 562 incident non-invasive intracranial CNS tumors occurred among 791,710 middle-aged women.
Risk among women who ever used a mobile phone compared to women who never used a mobile phone was not increased for all intracranial CNS tumors (RR 1.01, CI 0.90-1.14), for specified CNS tumor types nor for cancer at 18 other specified sites. For long-term users compared with never users, there was no appreciable association for glioma (≥ 10 years: RR 0.78, 0.55-1.10) or meningioma (≥ 10 years: RR 1.10, CI 0.66-1.84). For acoustic neuroma, there was an increase in risk with long term use vs never use (≥ years: RR 2.46, CI 1.07-5.64), the risk increasing with duration of use (trend among users, P 0.03). National incidence data showed no overall increase in the incidence of acoustic neuroma in either men or women at ages 20-79 years in England from 1998 to 2008.
The authors concluded that mobile phone use was not associated with increased incidence of glioma, meningioma or non-CNS cancers in this large prospective study.
Study funded by
Medical Research Council, UK
Cancer Research UK
National Health Service Breast Screening Programme, UK
Comments on this article
Benson VS et al.
Authors' response to: The case of acoustic neuroma: comment on mobile phone use and risk of brain neoplasms and other cancers.
de Vocht F
The case of acoustic neuroma: Comment on: Mobile phone use and risk of brain neoplasms and other cancers.