Epidemiological study (observational study)

Cellular telephone use and risk of acoustic neuroma.

Published in: Am J Epidemiol 2004; 159 (3): 277-283

Aim of study (acc. to author)

The possible association between cellular telephone use and the risk of acoustic neuroma was investigated in this Danish nationwide population-based case-control study.

Further details

The study is part of the INTERPHONE project. Regular use of mobile phone was defined as more than one call per week for 6 months or more.

Endpoint/type of risk estimation

Type of risk estimation:
  • incidence
(odds ratio (OR))

Exposure

Assessment

  • Type of assessment: Individual
  • interview: regular use, number of different cell phones, number of calls, use of handset and handsfree set
  • calculation: lifetime number of calls, lifetime number of hours of use

Exposure groups

Reference group 1 never used or less than once per week for six month
Group 2 use regularly
Group 3 time since first regular use never or rarely used < 1 year
Group 4 time since first regular use 1-4 year
Group 5 time since first regular use ≥ 5 year
Group 6 time since first regular use 5-9 year
Group 7 time since first regular use ≥ 10 year
Group 8 first telephone operating system: no information
Group 9 first telephone operating system: analogue
Group 10 first telephone operating system: digital
Group 11 lifetime cumulative number of calls ≤ 2975
Group 12 lifetime cumulative number of calls > 2975-11500
Group 13 lifetime cumulative number of calls > 11500
Group 14 lifetime cumulative hours of use ≤ 167.5
Group 15 lifetime cumulative hours of use > 167.5-654
Group 16 lifetime cumulative hours ofuse > 654
Group 17 cumulative use before diagnosis < 5 years
Group 18 cumulative use before diagnosis ≥ 5 years (≤ 81.7 hours)
Group 19 cumulative use before diagnosis ≥ 5 years (> 81.7 hours)

Population

  • Group:
    • men
    • women
  • Age: 20–69 yr
  • Observation period: September 2000 - August 2002
  • Study location: Denmark

Case group

Control group

  • Selection:
    • population-based
  • Matching:
    • sex
    • age
    • case:control = 1:2

Study size

Cases Controls
Eligible 141 332
Contacted 106 214
Participants 106 212
Statistical analysis method:
  • conditional logistic regression
( adjustment:
  • age
  • sex
  • residential area
  • education
  • marital status, use of hands-free device
)

Conclusion (acc. to author)

The results showed no evidence for an association between cellular telephone use and the risk of acoustic neuroma.

Study funded by

  • European Union (EU)/European Commission
  • Danish Cancer Society
  • International Union against Cancer (UICC; Union Internationale Contre le Cancer), Switzerland

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