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Medical/biological study (experimental study)

A comparative study on effects of static electric field and power frequency electric field on hematology in mice.

Published in: Ecotoxicol Environ Saf 2018; 166: 109-115

Aim of study (acc. to author)

To investigate the effects of a static electric field and a 50 Hz electric field on the immune system of mice.
Background/further details: In total, 120 male mice were used. Two experiments were performed: 1) Exposure to the static electric field (n=30) with a respective control group (n=30) and 2) Exposure to the 50 Hz electric field (n=30) and a respective control group (n=30). Mice were randomly assigned to the exposure or the control group. After 7, 14, or 21 days mice were sacrified (10 mice per group, respectively) and blood samples were taken.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: continuously for 7, 14, or 21 days
Exposure 2: 50 Hz
Exposure duration: continuously for 7, 14, or 21 days
Exposure 1
Main characteristics
Frequency
Type
Exposure duration continuously for 7, 14, or 21 days
Exposure setup
Chamber mice were housed in plastic cages (35 cm length, 25 cm width, 46 cm height) with top open
Setup exposure device consisted of a boost unit, a rectifier unit (only with the static electric field), a control unit and an electrode unit; the electrode unit consisted of two parallel electrode plates with a distance of 100 cm between the plates; the lower electrode was grounded; cages were placed on the lower electrode plate
Additional info the cages of the control group were placed on the ground below the lower electrode plate
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 35 kV/m - measured - ± 1.1 kV/m
Measurement and calculation details
measured about 8 cm above the bottom of the cage
Exposure 2
Main characteristics
Frequency 50 Hz
Type
Exposure duration continuously for 7, 14, or 21 days
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 35 kV/m - measured - ± 0.9 kV/m
Measurement and calculation details
measured about 8 cm above the bottom of the cage
Reference articles
  • Wu S et al. (2017): Does static electric field from ultra-high voltage direct-current transmission lines affect male reproductive capacity? Evidence from a laboratory study on male mice.
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No significant differences in all examined parameters were found between static electric field exposed mice and their respective control group (experiment 1).
In mice exposed to the 50 Hz electric field, the number of white blood cells (after 7, 14, and 21 days), red blood cells (after 7 days) and the hemoglobin concentration (after 21 days) were significantly reduced in comparison to control mice. However, the proportion of different types of white blood cells was unchanged (experiment 2).
The authors conclude that 50 Hz electric fields could impair the function of the immune system in mice while static electric fields do not have an effect.
Study character:

Study funded by

  • not stated/no funding

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  • Schmiedchen K et al. (2018): Systematic review of biological effects of exposure to static electric fields. Part II: Invertebrates and plants.
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  • Hori T et al. (2018): Characterization of the suppressive effects of extremely-low-frequency electric fields on a stress-induced increase in the plasma glucocorticoid level in mice.
  • Zhang D et al. (2017): Resveratrol may reverse the effects of long-term occupational exposure to electromagnetic fields on workers of a power plant.
  • Petri AK et al. (2017): Biological effects of exposure to static electric fields in humans and vertebrates: a systematic review.
  • Harakawa S et al. (2017): Time-dependent changes in the suppressive effect of electric field exposure on immobilization-induced plasma glucocorticoid increase in mice.
  • Hori T et al. (2017): Configuration-dependent variability of the effect of an electric field on the plasma glucocorticoid level in immobilized mice.
  • Güler G et al. (2006): Effects of static and 50 Hz alternating electric fields on superoxide dismutase activity and TBARS levels in guinea pigs.