研究のタイプ: 治療に関する研究 (experimental study)

[全身と深部局所の同時的な電磁ハイパサーミアを可能にするHF EM装置] tech./dosim.

A HF EM installation allowing simultaneous whole body and deep local EM hyperthermia

著者: Mazokhin VN, Kolmakov DN, Lucheyov NA, Gelvich EA, Troshin II
掲載誌: Int J Hyperthermia 1999; 15 (4): 309-329
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この研究は、全身用ハイパサーミア（WBH）および深部局所ハイパサーミア（DLH）に必要な電磁界を生成する、新しいアプローチに基づく高周波電磁界装置の構造および主な特徴について議論している。患者が蒸留水で満たされたボーラスの上に横たわり、ボーラスの下に配置された共平面容量型アプリケータから13.56 MHzの電磁界が生成される。43.5℃までの必要な治療温度に効果的な全身加熱を保証する一方で、皮膚温度は39〜40.5℃と低く維持することができること、DLHは追加のアプリケータにより可能になることなどを報告している。

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研究目的（著者による）

To design and develop an installation which assures tolerant for the patient whole body hyperthermia procedures, being simple enough and convenient for the physician, and allowing additional local heating of the tumour simultaneously with whole body hyperthermia. The aim of the study is to describe and analyse the design, main features, and achieved parameters of the installation developed to achieve the above mentioned goals.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 13.56 MHz
ばく露2: 13.56 MHz
ばく露3: 40.68 MHz
ばく露4: 40.68 MHz

General information

All the phantoms used in this study were filled with saline solutions of 7 and 5 g of sodium chloride per liter of deionized water and the walls of the phantom plastic tanks were 2.5 mm thick.

ばく露1

主たる特性
周波数 13.56 MHz
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源／構造
  • whole body applicator
チャンバの詳細 human body phantom, 25 cm deep, its torso part 80 cm long x 40 cm wide
Additional information Whole body applicator consisting a resonant circuit coupled via an inductance to 2 coplaner copper electrodes covered with 4 cm thick water bolus
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W - 備考を参照のこと。 - upto 10 W
Additional parameter details

The relative SAR distributions at a depth of 10 mm were 0.2, 0.5 and 1 in the torso, 0.04 in the head, 0.16 in the leg and 0.14 in the arm, respectively.

ばく露2

主たる特性
周波数 13.56 MHz
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
チャンバの詳細 rectangular torso phantom/ 80 x 32 x 18 cm³
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W - 備考を参照のこと。 - upto 10 W
Additional parameter details

Essential relative SAR (40 % of SAR maximum) was achieved at a depth of upto 20 cm. Relative SAR distributions on the depth in the xz (x upto 15 cm, z upto 15 cm) and yz (y upto 20 cm, z upto 15 cm) planes were 0.4 to 0.7 and 0.2 to 0.7, respectively.

ばく露3

主たる特性
周波数 40.68 MHz
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源／構造
  • rectangular inductive applicator RIA-40 C and RIA-40 P
チャンバの詳細 Oval muscle phantom/ 60 x 40 x 24 cm³
Additional information Relative SAR distridution measured at a depth of 1 cm by RIA-40 C in xz plane (x upto 15 cm, z upto 20 cm) and yz plane (z upto 20 cm, y upto 15 cm) was 0.09 to 0.5 and 0.05 to 0.5, respectively and in the case RIA-40 C was 0.1 to 0.5 in zy plane (z upto 1 cm and y upto 15 cm) and 0 to 0.5 in zx plane ( z upto 10 cm, x upto 20 cm).
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W - 備考を参照のこと。 - upto 10 W

ばく露4

主たる特性
周波数 40.68 MHz
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源／構造
  • contact flexible microstrip applicator CFMA-40 L or CFMA-40 S
チャンバの詳細 Oval muscle phantom/ 60 x 35 x 22 cm³
Additional information Relative SAR distridution measured at a depth of 1 cm by CFMA-40 L in xz plane (x upto 10 cm, z upto 15 cm) was 0.1 to 1.0 and 0.1 to 1.0 for CFMA-40 S, respectively
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W - 備考を参照のこと。 - upto 10 W

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露中

研究の主なアウトカム（著者による）

The high frequency electromagnetic field, at a frequency of 13.56 MHz, is created by a coplanar capacity type applicator positioned under a distilled water filled bolus that the patient is lying on. The electromagnetic energy being released directly in the deep tissues ensures effective whole body heating to required therapeutic temperatures of up to 43.5°C. Skin temperature can be maintained as low as 39-40.5°C. For deep local hyperthermia, the installation is equipped with additional applicators and a generator operating at a frequency of 40.68 MHz. Controllable power output in the range of 100-800 W at a frequency of 13.56 MHz and 50-350 W at a frequency of 40.68 MHz allows accurate temperature control during whole body hyperthermia, deep local hyperthermia and whole body hyperthermia/deep local hyperthermia procedures. The scattered electromagnetic field strength measured in the vicinity of the operating installation does not exceed security standards.

研究の種別:

研究助成