この研究は、ストリップラインスロット伝送路を用いて、単離したカエル坐骨神経に高ピーク電力マイクロ波パルス（915 MHz）ばく露を与える一方、神経を6 ms間隔の2重パルス（毎秒50対の反復率）で刺激した。マイクロ波パルス（パルス幅0.5 msまたは3 ms、ピークSARは33-72 kW/ kgおよび6-13 kW/ kg）は、刺激と同期させるか、または非同期とした（50 pps）。マイクロ波ばく露中の神経の温度上昇は1.5-2.7 ℃の範囲内であった。その結果、ばく露を受けた神経では、複合活動電位（CAP）の振幅および波形積分値が急速に低下した；このような影響は、マイクロ波特異的であった（その理由は、従来法で神経を加熱した場合、反対の変化を生じたからである）；その影響は仮にあるとしても、その影響の大きさはマイクロ波パルスの強度とも神経活動電位に対する位相関係とも相関しなかった；CAPの開始およびピーク速度、ならびに神経の刺激に対する抑圧は、マイクロ波ばく露の影響を受けなかった、と報告している。
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To study the effects of nonthermal microwave electromagnetic fields on nerve function (compound action potential).
To carry out a detailed analysis of the nonthermal microwave effect dependence on modulation parameters, and to check Tigranyan's hypothesis.
Tigranyan found severe disturbances in nerve function if intense enough microwave pulses coincided with latent period of compound action potential (CAP) propagation (e.g. CAP amplitude diminished by 93-95 %, CAP velocity decreased by 35-40 %). Tigranyan proposed that microwave pulse energy converts into mechanical pulses, propagating in a spiral between Schwann cell membranes of the nerve sheath; because of the phase synchronism effect, this in turn evokes another pulse perpendicular to the nerve surface that is strong enough to damage the "active" nerve membrane.
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 90 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.5 ms |
| Repetition frequency | 50 Hz |
| Pulse type | rectangular |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | The stripline irradiator and the experimental chamber were placed in an anechoic box. All the inputs to the box were shielded or filtered. |
| ばく露装置の詳細 | The stripline slot irradiator consisted of two parallel metal strips on a dielectric base layer with the following dimensions: strip length 35.25 mm, width 2 mm, and thickness negligible. The distance between strips (slot) was 3.6 mm. An area of about 0.5 cm² near the end of the strips served as a bottom for the 0.2-ml bath provided with a fairly uniform field. The chamber was placed perpendicular to the slot to minimize irradiation of nerve sites situated in its lateral sections. |
| Sham exposure | A sham exposure was conducted. |
| Additional information | Nerves were stimulated using twin pulses separated by a 6-ms interval at a rate of 50 pairs/s. Microwave pulses were either synchronised with the stimuli in various manners or were asynchronous. The part of the nerve situated in the lateral chamber which was submerged into oil and out of the exposure zone served as control nerve site, and the other part which crossed the medial chamber filled with Ringer's solution served as exposed nerve site. For some sham exposed preparations, the saline was conventionally preheated by 3°C. |
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| ばく露時間 | continuous for 90 min |
| Modulation type | pulsed |
|---|---|
| Pulse width | 3 ms |
| Repetition frequency | 50 Hz |
| Pulse type | rectangular |
| ばく露の発生源／構造 |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
The exposed nerves underwent faster decrease of compound action potential amplitude and tracing integral; the effect was microwave-specific since the equivalent conventional heating of nerve produced the opposite changes. Compound action potential onset and peak velocities as well as nerve refractivity were not affected by microwave exposure. The severe disturbance of nerve function reported by Tigranyan were not detected, although the exposure conditions were the same.
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