Study type: Medical/biological study (experimental study)

Effects of exposure of newborn patched1 heterozygous mice to GSM, 900 MHz. med./bio.

Published in: Radiat Res 2007; 168 (6): 733-740

Aim of study (acc. to author)

To study whether Patched1 mice are susceptible to the effects of radiofrequency electromagnetic field exposure at mobile phone frequencies during the neonatal period.

Background/further details

Patched1 heterozygous knockout mouse (Ptc1+/-) is an animal model of multiorgan tumorigenesis in which ionizing radiation dramatically accelerates tumor development.
200 newborn Ptc1+/- mice and their wild-type littermates were used.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: 0.5 h/twice a day for 5 days (from day 2 to day 6 after birth) with a 6 h intervall between exposures
  • SAR: 0.4 W/kg average over mass (whole body)

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Charakteristic
Exposure duration 0.5 h/twice a day for 5 days (from day 2 to day 6 after birth) with a 6 h intervall between exposures
Modulation
Modulation type pulsed
Exposure setup
Exposure source
Setup mice fixed in two 120 cm long TEM cells
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.4 W/kg average over mass calculated whole body -

Reference articles

  • Crawford ML (2016): Generation of standard EM fields using TEM transmission cells
  • Ardoino L et al. (2005): A radio-frequency system for in vivo pilot experiments aimed at the studies on biological effects of electromagnetic fields.
  • Gatta L et al. (2003): Effects of in vivo exposure to GSM-modulated 900 MHz radiation on mouse peripheral lymphocytes.
  • Balzano Q et al. (2000): An efficient RF exposure system with precise whole-body average SAR determination for in vivo animal studies at 900 MHz.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Under the experimental conditions studied, there was no evidence of life shortening or tumorigenic effects of neonatal exposure to GSM radiofrequency exposure in a highly tumor-susceptible mouse model.

Study character:

Study funded by

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