Medical/biological study (experimental study)

50-Hz magnetic field (0.1-mT) alters c-fos mRNA expression of early post implantation mouse embryos and serum estradiol levels of gravid mice med./bio.

By: Shi Y, Bao X, Huo X, Shen Z, Song T

Published in: Birth Defects Res B Dev Reprod Toxicol 2005; 74 (2): 196-200

Pregnant mice were exposed to magnetic or sham fields during gestation day 5.5-8.5 to study the effects of sinusoidal magnetic fields on early pregnancy in mouse embryos and mice and on early embryo development.

Exposure	Parameters
Exposure 1: 50 Hz Exposure duration: continuous from gestation day 5.5 to gestation day 8.5	magnetic flux density: 100 µT unspecified

Frequency	50 Hz
Type	magnetic field
Waveform	sinusoidal
Exposure duration	continuous from gestation day 5.5 to gestation day 8.5

Exposure source	coil made up of two sub-coils which produced the same magnetic field
Additional info	22 pregnant mice were randomly divided into two groups and transferred to the coils.

Measurand	Value	Type	Method	Mass	Remarks
magnetic flux density	100 µT	unspecified	measured	-	-

Exposed system:

Investigated system:

The expression of c-fos mRNA of embryos under exposure was enhanced. 50 Hz, 0.1 mT magnetic exposure induced the decline of serum estradiol levels of pregnant mice on gestation day 8.5. General examinations of blood did not show significant differences between the exposure group and the sham exposure group.
Under the experimental conditions, 50 Hz, 0.1 mT sinusoidal magnetic fields affected the development of early pregnancy mouse embryos and the dams to some extent.

Study character:

Franczak A et al. (2020): Consequences of electromagnetic field (EMF) radiation during early pregnancy - androgen synthesis and release from the myometrium of pigs in vitro
Koziorowska A et al. (2018): Extremely low-frequency electromagnetic field (EMF) generates alterations in the synthesis and secretion of oestradiol-17β (E2) in uterine tissues: An in vitro study
Lahijani MS et al. (2011): Effects of 50 Hz electromagnetic fields on the histology, apoptosis, and expression of c-Fos and beta-catenin on the livers of preincubated white Leghorn chicken embryos
Komazaki S et al. (2007): Induction of increase in intracellular calcium concentration of embryonic cells and acceleration of morphogenetic cell movements during amphibian gastrulation by a 50-Hz magnetic field
Yao K et al. (2007): Absence of effect of power-frequency magnetic fields exposure on mouse embryonic lens development
Ohnishi Y et al. (2002): Effects of power frequency alternating magnetic fields on reproduction and pre-natal development of mice

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