Study type: Medical/biological study (experimental study)

Effects of 2.45-GHz microwave radiation and phorbol ester 12-O-tetradecanoylphorbol-13-acetate on dimethylhydrazine-induced colon cancer in mice. med./bio.

Published in: Bioelectromagnetics 1994; 15 (6): 531-538

Aim of study (acc. to author)

To investigate the effects of 2.45 GHz microwave radiation on dimethylhydrazine (DMH)-induced colon cancer in mice.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: repeated daily exposure, 3 h/day, 6 days/week, for 5 months

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration repeated daily exposure, 3 h/day, 6 days/week, for 5 months
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup Mice were individually housed in Plexiglas cages (8.5 cm x 3.5 cm x 3.5 cm) and exposed dorsally with the E field parallel to their long body axis. Cage positions were selected according to the desired power density and shifted counter clockwise each day for a uniform total exposure.
Sham exposure A sham exposure was conducted.
Additional info The animals were divided into four groups: control, DMH, DMH + MW, and DMH + TPA.
Parameters
Measurand Value Type Method Mass Remarks
power density 10 mW/cm² unspecified measured - -
SAR 12 W/kg mean estimated - 10-12 W/kg [Durney et al., 1978]

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The results indicate that 2.45 GHz microwave radiation did not promote DMH-induced colon cancer in young mice. The incidence of tumors did not significantly differ between the different groups. However, the number of tumors, the size of the tumors, and the incidence of protuberant and infiltrative types in tumor-bearing animals were higher in the group treated with DMH+TPA (12-O-tetradecanyolphorbol-13-acetate) in comparison to the groups treated with DMH only or with DMH+microwave. That means that TPA could accelerate colon tumor development if a tumor was initiated.

Study character:

Study funded by

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