Study type: Medical/biological study (experimental study)

Effect of radiofrequency radiation exposure on mouse skin tumorigenesis initiated by 7,12-dimethybenz[alpha]anthracene. med./bio.

Published in: Int J Radiat Biol 2005; 81 (12): 861-867

Aim of study (acc. to author)

To study if radiofrequency irradiation has a tumor promoting effect, mice with skin tumorigenesis initiated by DMBA (1000 µg/100 µl acetone/mouse on shaved dorsal skin) were exposed to radiofrequency irradiation

Background/further details

One week after DMBA treatment, the animals were randomized into four equal groups of 20 mice each: sham exposed, 849 MHz-, 1,763 MHz-exposed, and TPA-treated (as positive control) groups.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 848.5 MHz
Exposure duration: repeated daily exposure, 45 min on/15 min off/45 min on, 5 days/week for 19 weeks
  • SAR: 0.4 W/kg average over mass (whole body)
Exposure 2: 1,762.5 MHz
Exposure duration: repeated daily exposure, 45 min on/15 min off/45 min on, 5 days/week for 19 weeks
  • SAR: 0.4 W/kg average over mass (whole body)

General information

Mice were randomly divided into four exposure groups: 849 MHz-exposed, 1763 MHz-exposed, sham-exposed and TPA-treated.

Exposure 1

Main characteristics
Frequency 848.5 MHz
Type
Exposure duration repeated daily exposure, 45 min on/15 min off/45 min on, 5 days/week for 19 weeks
Modulation
Modulation type cf. additional info
Additional info

CDMA signal for cellular system

Exposure setup
Exposure source
Chamber reverberation chamber (2293 x 2296 x 1700 mm³) made of stainless steel and fitted with a mode stirrer for field uniformity
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.4 W/kg average over mass measured and calculated whole body -

Exposure 2

Main characteristics
Frequency 1,762.5 MHz
Type
Exposure duration repeated daily exposure, 45 min on/15 min off/45 min on, 5 days/week for 19 weeks
Modulation
Modulation type cf. additional info
Additional info

CDMA signal for personal communication service (PCS)

Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.4 W/kg average over mass measured and calculated whole body -

Reference articles

  • Jung KB et al. (2008): Development and validation of reverberation-chamber type whole-body exposure system for mobile-phone frequency.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The results suggest that 849 MHz and 1763 MHz radiofrequency irradiations, similar to those emitted from mobile phones, do not have any tumor promoting effect on skin tumor development in DMBA-initiated mice. Skin tumors were observed only in the TPA-treated positive control group.

Study character:

Study funded by

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