A Y-maze was used that is based on the innate tendency of rodents to explore novel environments: During the first trial, the mouse was allowed to explore only two arms of the maze (third arm blocked by a door). During the second trial, the door is opened and all three arms are accessible. Discrimination of novelty versus familiarity can be studied by comparing an animal's exploration of all three arms.
National Basic Research Program (Program 973), China
Chinese-Finnish International Collaboration Project NEURO
National Key Technologies R&D Program, China
National High-tech R&D Program (863 Program), China
Program of CASC
Yunnan Science and Technique Program, China
Major State Basic Research Development Program, China
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