Study type: Medical/biological study (experimental study)

Acute radio frequency irradiation does not affect cell cycle, cellular migration, and invasion. med./bio.

Published in: Bioelectromagnetics 2008; 29 (8): 615-625

Aim of study (acc. to author)

To study whether radiofrequency exposure exerts detectable effects on cell cycle distribution, cellular invasion, and migration.

Background/further details

Radiofrequency exposure was conducted under isothermal conditions. For the positive control group experiments, the cells were exposed to various doses of gamma radiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 849 MHz
Exposure duration: continuous for 1 h
  • SAR: 2 W/kg spatial average
  • SAR: 10 W/kg spatial average
Exposure 2: 849 MHz
Exposure duration: repeated daily exposure, 1 h/day, for 3 days
  • SAR: 2 W/kg spatial average
  • SAR: 10 W/kg spatial average

Exposure 1

Main characteristics
Frequency 849 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 1 h
Modulation
Modulation type cf. additional info
Additional info

real CDMA test signal

Exposure setup
Exposure source
Chamber The exposure system was fed with a λ/8 monopole antenna (33 mm long) at the λ/4 position of the top plate of the cavity to excite only the fundamental TE102 mode, and it allowed for the uniform exposure of one 100-mm culture plate. The gas from an incubator was circulated throughout the chamber to maintain CO2 density and humidity. Additionally, cooling water was circulated through the bottom of the cavity to maintain the temperature at 37 ± 0.3°C.
Setup The cells were exposed in a 100-mm Petri dish (I.D. 85 mm) in 18 ml of culture medium at 4 mm height.
Sham exposure A sham exposure was conducted.
Additional info The exposure system was warmed up for 30 min to equilibrate it prior to RF exposure.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 W/kg spatial average measured - -
SAR 10 W/kg spatial average measured - -

Exposure 2

Main characteristics
Frequency 849 MHz
Type
Charakteristic
  • guided field
Exposure duration repeated daily exposure, 1 h/day, for 3 days
Modulation
Modulation type cf. additional info
Additional info

real CDMA test signal

Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 W/kg spatial average measured - -
SAR 10 W/kg spatial average measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that 849 MHz radiofrequency exposure exerts no detectable effects on cell cycle distribution, cellular migration, or invasion at average SAR values of 2 or 10 W/kg.

Study character:

Study funded by

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