Study type: Medical/biological study (experimental study)

Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins. med./bio.

Published in: Bioelectromagnetics 2011; 32 (3): 169-178

Aim of study (acc. to author)

To study whether single or combined radiofrequency exposure (W-CDMA and CDMA) has effects on the cell cycle and its regulatory proteins.

Background/further details

After exposure, the cells were immediately transferred to a cell culture incubator and kept for the indicated post-exposure time (0, 2, 10, 24, or 48 h) before harvesting the cells.
The positive control was exposed to 0.5 or 4 Gy doses of ionizing radiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 837 MHz
Exposure duration: continuous for 1 h either CDMA (4 W/kg) alone or simultaneously CDMA (2 W/kg) and WCDMA (2 W/kg)
Exposure 2: 1,950 MHz
Exposure duration: continuous for 1 h simultaneously CDMA (2 W/kg) and WCDMA (2 W/kg)

Exposure 1

Main characteristics
Frequency 837 MHz
Type
Exposure duration continuous for 1 h either CDMA (4 W/kg) alone or simultaneously CDMA (2 W/kg) and WCDMA (2 W/kg)
Additional info CDMA
Exposure setup
Exposure source
Chamber 100 mm Petri dish (inner diameter of 85 mm, walls 1 mm thick) in 950 mm x 950 mm x 226 mm aluminum exposure unit
Setup environment in exposure unit controlled to maintain temperature, humidity and CO2 density
Sham exposure A sham exposure was conducted.
Additional info both signals (CDMA and WCDMA) amplified and applied to a radial transmission line
Parameters
Measurand Value Type Method Mass Remarks
power 60 W maximum - - input power
SAR 0.105 W/kg mean measured - -

Exposure 2

Main characteristics
Frequency 1,950 MHz
Type
Exposure duration continuous for 1 h simultaneously CDMA (2 W/kg) and WCDMA (2 W/kg)
Additional info WCDMA
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power 60 W maximum - - input power
SAR 0.262 W/kg mean measured - -

Reference articles

  • Pickard WF et al. (2000): Experimental and numerical determination of SAR distributions within culture flasks in a dielectric loaded radial transmission line.
  • Moros EG et al. (1999): The radial transmission line as a broad-band shielded exposure system for microwave irradiation of large numbers of culture flasks.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Main outcome of study (acc. to author)

Neither the single radiofrequency exposure nor the combined radiofrequency exposure elicited alterations in DNA synthesis, cell cycle distribution, and levels of cell cycle regulatory proteins. These data indicate that neither single nor combined radiofrequency exposure affect cell cycle progression.

Study character:

Study funded by

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