Lack of genotoxic effects (micronucleus induction) in human lymphocytes exposed in vitro to 900 MHz electromagnetic fields med./bio.

Aim of study (acc. to author)

Endpoint

• genotoxicity/mutation: incidence of micronuclei
• cell viability/cell division/proliferation: cell cycle kinetics

Exposure

• • mobile communications
  • GSM

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• genotoxicity/mutation: incidence of micronuclei (cytokinesis block micronucleus assay; micronucleus frequency)
• cell viability/cell division/proliferation: cytotoxicity (cell cycle kinetics; cytokinesis-block proliferation index (M1+2M2+3(M3+M4)/total number of cells; M1 to M4: number of cells with 1 to 4 nuclei); binucleated cell index (number of binucleated cells/500 cells))

Main outcome of study (acc. to author)

Study funded by

• Telecom Italia Mobile (TIM)

Related articles

• Waldmann P et al. (2013): Influence of GSM Signals on Human Peripheral Lymphocytes: Study of Genotoxicity
• Speit G et al. (2013): Genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in HL-60 cells are not reproducible
• Hintzsche H et al. (2012): 900 MHz radiation does not induce micronucleus formation in different cell types
• Hintzsche H et al. (2010): Micronucleus frequency in buccal mucosa cells of mobile phone users
• Mazor R et al. (2008): Increased levels of numerical chromosome aberrations after in vitro exposure of human peripheral blood lymphocytes to radiofrequency electromagnetic fields for 72 hours
• Lee JJ et al. (2008): Acute radio frequency irradiation does not affect cell cycle, cellular migration, and invasion
• Speit G et al. (2007): Genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in cultured mammalian cells are not independently reproducible
• Chauhan V et al. (2007): Evaluating the biological effects of intermittent 1.9 GHz pulse-modulated radiofrequency fields in a series of human-derived cell lines
• Baohong W et al. (2007): Evaluating the combinative effects on human lymphocyte DNA damage induced by ultraviolet ray C plus 1.8 GHz microwaves using comet assay in vitro
• Juutilainen J et al. (2007): Micronucleus frequency in erythrocytes of mice after long-term exposure to radiofrequency radiation
• Maes A et al. (2006): Cytogenetic investigation of subjects professionally exposed to radiofrequency radiation
• Scarfi MR et al. (2006): Exposure to radiofrequency radiation (900 MHz, GSM signal) does not affect micronucleus frequency and cell proliferation in human peripheral blood lymphocytes: an interlaboratory study
• Gurisik E et al. (2006): An in vitro study of the effects of exposure to a GSM signal in two human cell lines: monocytic U937 and neuroblastoma SK-N-SH
• Lantow M et al. (2006): Comparative study of cell cycle kinetics and induction of apoptosis or necrosis after exposure of human mono mac 6 cells to radiofrequency radiation
• Gandhi G et al. (2005): Genetic damage in mobile phone users: some preliminary findings
• Gandhi G et al. (2005): Cytogenetic damage in mobile phone users: preliminary data