To study the effect of CDMA mobile phone signals on DNA integrity in human leukocytes. The effect of aphidicolin on DNA damage induced by radiofrequency signals was also investigated (to study DNA repair efficiency).
Exposure duration: continuous for 1 h and 2 h
blood samples were treated in the following ways: i) EMF exposure ii)sham exposure iii) 0.2 µg/ml APC added iv) 2 µg/ml APC added v) 0.2 µg/ml APC added + EMF exposure vi) 2 µg/ml APC added + EMF exposure
The data showed that CDMA radiofrequency electromagnetic fields alone did not induce a significant DNA damage in exposed blood samples while in combination with the DNA repair inhibitor aphidicolin the DNA damage was significant. Aphidicolin alone (at 2 µg/ml) also showed significant DNA damage levels when compared to sham exposed samples. DNA repair efficiency also varied in a significant way in combinative exposure sets (2 µg/ml was relatively more effective as DNA repair inhibitor than 0.2 µg/ml).
The data suggest that the DNA repair inhibitor aphidicolin enhances DNA damage at 2 µg/ml and that the damage is possibly repairable. Thus, the in vitro exposure to radiofrequency signals induces reversible DNA damage in synergism with aphidicolin.