Study type: Medical/biological study (experimental study)

Combinative Exposure Effect of Radio Frequency Signals from CDMA Mobile Phones and Aphidicolin on DNA Integrity. med./bio.

Published in: Electromagn Biol Med 2008; 27 (4): 418-425

Aim of study (acc. to author)

To study the effect of CDMA mobile phone signals on DNA integrity in human leukocytes. The effect of aphidicolin on DNA damage induced by radiofrequency signals was also investigated (to study DNA repair efficiency).

Background/further details

Aphidicolin is a compound with anti-mitotic properties and is known as DNA repair inhibitor.
Blood samples were taken from six healthy males.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 835 MHz
Exposure duration: continuous for 1 h and 2 h
  • SAR: 1.17 W/kg

General information

blood samples were treated in the following ways: i) EMF exposure ii)sham exposure iii) 0.2 µg/ml APC added iv) 2 µg/ml APC added v) 0.2 µg/ml APC added + EMF exposure vi) 2 µg/ml APC added + EMF exposure

Exposure 1

Main characteristics
Frequency 835 MHz
Type
Exposure duration continuous for 1 h and 2 h
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1.17 W/kg - - - -

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that CDMA radiofrequency electromagnetic fields alone did not induce a significant DNA damage in exposed blood samples while in combination with the DNA repair inhibitor aphidicolin the DNA damage was significant. Aphidicolin alone (at 2 µg/ml) also showed significant DNA damage levels when compared to sham exposed samples. DNA repair efficiency also varied in a significant way in combinative exposure sets (2 µg/ml was relatively more effective as DNA repair inhibitor than 0.2 µg/ml).
The data suggest that the DNA repair inhibitor aphidicolin enhances DNA damage at 2 µg/ml and that the damage is possibly repairable. Thus, the in vitro exposure to radiofrequency signals induces reversible DNA damage in synergism with aphidicolin.

Study character:

Study funded by

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