Study type: Medical/biological study (experimental study)

Increased levels of numerical chromosome aberrations after in vitro exposure of human peripheral blood lymphocytes to radiofrequency electromagnetic fields for 72 hours. med./bio.

Published in: Radiat Res 2008; 169 (1): 28-37

Aim of study (acc. to author)

This study was designed to examine whether the exposure to 800 MHz electromagnetic field affects the number of chromosomes in human peripheral blood lymphocytes in vitro.

Background/further details

The human peripheral blood lymphocytes were obtained from 14 healthy male donors (23 to 39 years old). After exposure for 72 hours at two different specific absorption rates (2.9 and 4.1 W/kg) the chromosomes 1, 10, 11, and 17 were further investigated. Additionally, the effects of the temperature on the number of these chromosomes were determined in four samples incubated at 33.5, 37, 38.5, 40 °C.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 800 MHz
Modulation type: CW
Exposure duration: continuous for 72 h with a short break for handling every 24 h
  • SAR: 2.9 W/kg average over mass (1 g)
  • SAR: 4.1 W/kg average over mass (1 g)
  • SAR: 1 W/kg spatial average (1 - 8 W/kg calculated from experimental temperature measurements)

Exposure 1

Main characteristics
Frequency 800 MHz
Type
Exposure duration continuous for 72 h with a short break for handling every 24 h
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup 43 cm x 33 cm waveguide resonator
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2.9 W/kg average over mass calculated 1 g -
SAR 4.1 W/kg average over mass calculated 1 g -
SAR 1 W/kg spatial average calculated - 1 - 8 W/kg calculated from experimental temperature measurements

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Increased levels of aneuploidy depending on the chromosome studied as well as on the level of exposure were found. In chromosomes 1 and 10, there was increased aneuploidy at the higher specific absorption rate of 4.1 W/kg, while for chromosomes 11 and 17, the increases were observed only for the lower specific absorption rate of 2.9 W/kg.
No statistically significant effect of temperature on the level of aneuploidy was observed over the range of 33.5-40 °C compared to 37 °C.
These results suggest the possible existence of an athermal effect of radio frequency irradiation that causes increased levels of aneuploidy.

Study character:

Study funded by

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