EMF-Portal | Cytogenetic investigations on microwaves emitted by a 455.7 MHz car phone

Cytogenetic investigations on microwaves emitted by a 455.7 MHz car phone med./bio.

By: Maes A, Collier M, Verschaeve L

Published in: Folia Biol 2000; 46 (5): 175-180

Aim of study (acc. to author)

Background/further details

Endpoint

Exposure

Exposure	Parameters
Exposure 1: 455.7 MHz Exposure duration: continuous for 2 h	electric field strength: 50 V/m SAR: 6.5 W/kg

Exposure 1

Main characteristics

Frequency	455.7 MHz
Type	electromagnetic field
Charakteristic	near field
Exposure duration	continuous for 2 h

Exposure setup

Exposure source	cellular phone
Distance between exposed object and exposure source	5 cm
Setup	Blood samples were placed in a cooled box at 17 ± 1 °C at 5 cm from the antenna of an analogue car phone.
Additional info	The following kinds of exposure were investigated: MW or MMC or X-ray exposure alone, MW exposure followed by MMC, and MW exposure followed by X-rays. MW and X-ray (5 doses) exposures preceded cell cultivation. MMC (2 doses) was present during all 72 h of cell cultivation. Control samples were kept in the same conditions of temperature and humidity as the exposed ones. X-ray exposed blood samples were irradiated at room temperature with doses of 5, 10, 20, 30 or 100 cGy at a dose rate of 1 Gy/min.

Parameters

Measurand	Value	Type	Method	Mass	Remarks
electric field strength	50 V/m	-	measured	-	-
SAR	6.5 W/kg	-	calculated	-	-

Measurement and calculation details

The field distribution in the near field was not uniform, therefore evaluation was very approximated.

Exposed system:

blood samples

Methods Endpoint/measurement parameters/methodology

Investigated system:

intact cell/cell culture
chromosomes/chromatids

Time of investigation:

after exposure

Main outcome of study (acc. to author)

In the present investigation it was not possible to demonstrate any effect of 455.7 MHz electromagnetic fields on the genetic material of white blood cells in vitro. The data do not support the hypothesis that radiofrequency fields act synergistically with chemical (in this case Mitomycin C) or physical (e.g. X-rays) mutagens.

Study character:

medical/biological study
experimental study
full/main study

Study funded by

not stated/no funding

Bourthoumieu S et al. (2010): Cytogenetic Studies in Human Cells Exposed In Vitro to GSM-900 MHz Radiofrequency Radiation Using R-Banded Karyotyping

Zhijian C et al. (2010): Impact of 1.8-GHz radiofrequency radiation (RFR) on DNA damage and repair induced by doxorubicin in human B-cell lymphoblastoid cells

Mazor R et al. (2008): Increased levels of numerical chromosome aberrations after in vitro exposure of human peripheral blood lymphocytes to radiofrequency electromagnetic fields for 72 hours

Tiwari R et al. (2008): Combinative Exposure Effect of Radio Frequency Signals from CDMA Mobile Phones and Aphidicolin on DNA Integrity

Stronati L et al. (2006): 935 MHz cellular phone radiation. An in vitro study of genotoxicity in human lymphocytes

Gandhi G et al. (2005): Genetic damage in mobile phone users: some preliminary findings

Maes A et al. (2001): Cytogenetic effects of 900 MHz (GSM) microwaves on human lymphocytes

Maes A et al. (1997): Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C

Maes A et al. (1996): 954 MHz microwaves enhance the mutagenic properties of mitomycin C